Genetic polymorphism in the manganese superoxide dismutase gene is associated with an increased risk for hepatocellular carcinoma in HCV-infected Moroccan patients

Autor: M. Benazzouz, Rajae Afifi, Mohammed Hassar, Abdellah Essaid El Feydi, Abdelaziz Chafik, Soumaya Benjelloun, Pascal Pineau, Latifa El Kihal, Sayeh Ezzikouri
Přispěvatelé: Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), CHU Ibn-Sina [Rabat] (CHUIS), Laboratoire d'Anthropogénétique et Biostatistique [El Jadida, Maroc], Faculté des Sciences [El Jadida. Maroc], Université Chouaib Doukkali (UCD)-Université Chouaib Doukkali (UCD), Organisation Nucléaire et Oncogenèse, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), The authors would like to acknowledge all patients for their participation in this study. We are particularly grateful to Benoit Robert and Michele Joliy for their advice and encouragements., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2008
Předmět:
Male
MnSOD
Hepatocellular carcinoma
Health
Toxicology and Mutagenesis
Hepacivirus
MESH: Alanine / genetics
medicine.disease_cause
MESH: Genotype
0302 clinical medicine
Gene Frequency
Risk Factors
MESH: Risk Factors
Genotype
Odds Ratio
MESH: Aged
0303 health sciences
Alanine
MESH: Middle Aged
biology
Hepatitis C virus
MESH: Genetic Predisposition to Disease
MESH: Valine / genetics
Valine
Hepatitis C
Middle Aged
Hepatitis B
3. Good health
Morocco
030220 oncology & carcinogenesis
Female
MESH: Hepatitis C / complications
Carcinoma
Hepatocellular
MESH: Carcinoma
Hepatocellular / etiology
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Polymorphism
Genetic
03 medical and health sciences
Ala-9Val polymorphism
MESH: Gene Frequency
Genetics
medicine
Humans
Genetic Predisposition to Disease
MESH: Superoxide Dismutase / genetics
Aged
030304 developmental biology
Polymorphism
Genetic
MESH: Humans
Superoxide Dismutase
MESH: Carcinoma
Hepatocellular / genetics
Cancer
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Odds ratio
medicine.disease
biology.organism_classification
MESH: Male
MESH: Odds Ratio
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
MESH: Morocco
Immunology
MESH: Female
Zdroj: Mutation Research-Genetic Toxicology and Environmental Mutagenesis
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2008, 649 (1-2), pp.1-6. ⟨10.1016/j.mrgentox.2007.05.019⟩
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, Elsevier, 2008, 649 (1-2), pp.1-6. ⟨10.1016/j.mrgentox.2007.05.019⟩
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2007.05.019
Popis: International audience; Hepatocellular carcinoma (HCC) ranks among the 10 most common cancers worldwide. The main risk factors for its development are hepatitis B and C virus infections. Hepatitis B and C viruses induce chronic inflammation and oxidative stress that could predispose a cell to mutagenesis and proliferation. Manganese superoxide dismutase (MnSOD) catalyses the detoxification of free radicals, thus playing a crucial role in the protection against damage. A valine (Val) to alanine (Ala) substitution at amino acid 9, mapping within the mitochondrion-targeting sequence of the MnSOD gene, has been associated with an increased cancer risk. The aim of our study was to investigate a possible association of the Val/Ala-MnSOD polymorphism and HCC development in Moroccan patients. Genotypes were determined by means of PCR and RFLP analysis in 96 patients with HCC and 222 control subjects matched for age, sex, and ethnicity. Homozygous Ala/Ala carriers were 31% in the cases and 18% in the controls, which corresponds to an odds ratio (OR) of 2.89, with a 95% confidence interval (CI) of 1.47-5.68. Stratification into subgroups based on HCV infection status revealed an even more increased risk for homozygous Ala/Ala carriers with hepatitis C infection (38.2% in the cases versus 14.8% in the control subjects OR, 5.09; 95% CI, 1.76-14.66). Our findings provide further evidence of an association between the Ala-9Val MnSOD polymorphism and HCC occurrence in hepatitis C virus-infected Moroccan patients.
Databáze: OpenAIRE
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