Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell Encapsulation
| Autor: | Di Wu, Yangjun Chen, Wenda Wang, Diana Diaz-Dussan, Kazuhiko Ishihara, Ravin Narain, Anika Benozir Asha, Yi-Yang Peng, Dennis G. Hall |
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| Rok vydání: | 2022 |
| Předmět: |
chemistry.chemical_classification
Catechol Polymers and Plastics Organic Chemistry Dynamic covalent chemistry 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Covalent bond Self-healing Self-healing hydrogels Materials Chemistry Copolymer 0210 nano-technology Cell encapsulation |
| Zdroj: | ACS macro letters. 7(8) |
| ISSN: | 2161-1653 |
| Popis: | Boronic ester, one typical example of dynamic covalent bonds, has presented great potential to prepare self-healing hydrogels. However, most of currently reported hydrogels based on boronic esters are formed at pH > 8, which impeded their further use in physiological conditions. In this study, we designed two kinds of zwitterionic copolymers with benzoxaborole and catechol pendant groups, respectively. Owing to the lower pKa value of benzoxaborole (7.2), gelation can happen easily at pH 7.4 PBS after mixing these two copolymers due to efficient formation of benzoxaborole-catechol complexations. The resulting hydrogels exhibited excellent self-healing property as well as dual pH/sugar responsiveness due to the dynamic nature of boronic ester. Moreover, benefiting from the cell membrane bioinspired 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymeric matrix, the hydrogel was further investigated for 3D cell encapsulation. The combination of biocompatible zwitterionic polymers with dynamic benzoxab... |
| Databáze: | OpenAIRE |
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