Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes
| Autor: | Marcel Kool, Fabian Kratochwil, Stefan Gröschel, Stefan M. Pfister, Dominik Sturm, Josef Zamecnik, Maia Segura Wang, Nada Jabado, Paul A. Northcott, Peter Lichter, Peter van Sluis, Carl Hermann, Susanne Bens, Pascal Johann, Andrea Wittmann, Reinhard Schneppenheim, Katja Beck, Ulrich Schüller, Kornelius Kerl, Florian Oyen, Sebastian Brabetz, Michael A. Grotzer, Marc Zapatka, Jaume Mora, Jan Koster, Laura Sieber, Richard Volckmann, Eleonora Aronica, David Sumerauer, Marina Rhyzova, Annie Huang, David T.W. Jones, Roland Eils, Stefan Wolf, Serap Erkek, Susanne Gröbner, Lukas Chavez, Anna Marta Maria Bertoni, Michael C. Frühwald, Christina Geörg, Rogier Versteeg, Volker Hovestadt, Till Milde, Michael D. Taylor, Andreas von Deimling, Torsten Pietsch, Reiner Siebert, David Capper, Jan O. Korbel, Martin Hasselblatt, Tarek Shalaby, Bernhard Radlwimmer, Olaf Witt, Ivo Buchhalter, Andrey Korshunov, Andreas E. Kulozik, Amar Gajjar, Martin Ebinger |
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| Přispěvatelé: | Cellular and Computational Neuroscience (SILS, FNWI), Oncogenomics, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, ANS - Cellular & Molecular Mechanisms, Pathology, APH - Amsterdam Public Health, Other departments |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Chromosomal Proteins Non-Histone Bisulfite sequencing Biology medicine.disease_cause Article Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine medicine Humans Epigenetics SMARCB1 Enhancer Rhabdoid Tumor Epigenesis Genetics Mutation Brain Neoplasms Teratoma SMARCB1 Protein Cell Biology medicine.disease DNA-Binding Proteins 030104 developmental biology Oncology 030220 oncology & carcinogenesis Atypical teratoid rhabdoid tumor Cancer research Transcription Factors |
| Zdroj: | Cancer Cell r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Cancer Cell, 29(3), 379-393. Cell Press Cancer cell, 29(3), 379-393. Cell Press |
| ISSN: | 1535-6108 |
| Popis: | Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigenetically analyzed 192 ATRTs. Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified. Whole-genome DNA and RNA sequencing found no recurrent mutations in addition to SMARCB1 that would explain the differences between subgroups. Whole-genome bisulfite sequencing and H3K27Ac chromatin-immunoprecipitation sequencing of primary tumors, however, revealed clear differences, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets. |
| Databáze: | OpenAIRE |
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