Prognostic Role of microRNA-205 in Human Gynecological Cancer: A Meta-Analysis of Fourteen Studies
| Autor: | Qingjian Ye, Huichao Liang, Tingting Xia, Dong Liu, Qian Xiong, Zhixi Wu, Hong Tang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Bioinformatics analysis Breast Neoplasms Biology 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine microRNA Genetics medicine Humans Prognostic biomarker Molecular Biology Endometrial cancer Cell Biology General Medicine medicine.disease Prognosis Gynecological cancer Endometrial Neoplasms MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Female |
| Zdroj: | DNA and cell biology. 39(5) |
| ISSN: | 1557-7430 |
| Popis: | Several studies have revealed that miR-205 plays important roles in the development of gynecological cancers and thus may serve as a potential prognostic biomarker, but the current conclusions remain controversial. Therefore, the goal of this study was to explore the prognostic significance and functional mechanisms of miR-205 based on a meta-analysis and bioinformatics investigation. A total of 14 published studies containing 5835 patients were enrolled by searching the PubMed, EMBASE, and Cochrane library databases, 13 (14 datasets) and 5 (6 datasets) of which evaluated the correlations between the expression level of miR-205 and overall survival (OS) or disease-free survival (DFS)/disease-specific survival (DSS)/progression-free survival (PFS)/distant metastasis-free survival (DMFS), respectively. Furthermore, the use of online Kaplan-Meier plotter database analysis supplemented another seven results for OS. Then, a meta-analysis using these 21 and 6 datasets was performed. As a result, the overall analysis failed to demonstrate any significant associations between miR-205 expression and OS ( |
| Databáze: | OpenAIRE |
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