Comparative genomic and phylogeographic analysis of Mycobacterium leprae.: Phylogeography of leprosy (titre du fichier auteur)
| Autor: | Monot, Marc, Honoré, Nadine, Garnier, Thierry, Zidane, Nora, Sherafi, Diana, Paniz-Mondolfi, Alberto, Matsuoka, Masanori, Taylor, G Michael, Donoghue, Helen D, Bouwman, Abi, Mays, Simon, Watson, Claire, Lockwood, Diana, Khamesipour, Ali, Khamispour, Ali, Dowlati, Yahya, Jianping, Shen, Rea, Thomas H, Vera-Cabrera, Lucio, Stefani, Mariane M, Banu, Sayera, Macdonald, Murdo, Sapkota, Bishwa Raj, Spencer, John S, Thomas, Jérôme, Harshman, Keith, Singh, Pushpendra, Busso, Philippe, Gattiker, Alexandre, Rougemont, Jacques, Brennan, Patrick J, Cole, Stewart T |
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| Přispěvatelé: | Instituto de Biomedicina, Instituto de biomedicina, Leprosy Research Centre [Japan], National Institute of Infectious Diseases [Tokyo], Centre for Infectious Diseases and International Health, UCL, Faculty of Life Sciences [Manchester], The University of Manchester [Manchester], Ancient Monuments Laboratory, English Heritage Centre for Archaeology, London School of Hygiene and Tropical Medicine (LSHTM), Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, National Center for Leprosy Control [China], Chinese Center for Disease Control and Prevention (China CDC), Department of Dermatology [Los Angeles, USA], Keck School of Medicine [Los Angeles], Servicio de Dermatología, Hospital Universitario José E. Gonzalez, Tropical Pathology and Public Health Institute [Brazil], Federal University of Goias, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Leprosy Mission Nepal, Anandaban Hospital [Nepal], Department of Microbiology, Immunology and Pathology, Colorado State University [Fort Collins] (CSU), Center for Integrative Genomics - Institute of Bioinformatics, Génopode (CIG), University of Lausanne, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Bioinformatics and Biostatistics Core Facility [Lausanne], This work received the financial support of the Fondation Raoul Follereau, the Génopole programme, and the US National Institutes of Health, National Institute of Allergy and Infectious Diseases (grant RO1-AI47197-01A1 and contract NO1-AI25469)., Instituto de Biomedicina [Caracas], Universidad Central de Venezuela (UCV), University of Manchester [Manchester], University of Southern California (USC)-University of Southern California (USC), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Global Health Institute - Institut d'Infectiologie [Lausanne] |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
MESH: Geography
Pseudogene Biology MESH: Genome Bacterial medicine.disease_cause [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology Polymorphism Single Nucleotide Genome Article 03 medical and health sciences Phylogenetics Leprosy Genetics medicine Humans MESH: Phylogeny Genotyping Mycobacterium leprae Phylogeny 030304 developmental biology Recombination Genetic Whole genome sequencing Comparative genomics Mycobacterium lepromatosis 0303 health sciences MESH: Humans Geography 030306 microbiology MESH: Polymorphism Single Nucleotide [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology biology.organism_classification MESH: Leprosy 3. Good health Genes Bacterial MESH: Recombination Genetic MESH: Mycobacterium leprae MESH: Genes Bacterial Genome Bacterial |
| Zdroj: | Nature Genetics Nature Genetics, Nature Publishing Group, 2009, 41 (12), pp.1282-9. <10.1038/ng.477> Nature Genetics, Nature Publishing Group, 2009, 41 (12), pp.1282-9. ⟨10.1038/ng.477⟩ |
| ISSN: | 1061-4036 1546-1718 |
| DOI: | 10.1038/ng.477> |
| Popis: | International audience; Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38x coverage) and NHDP63 (46x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy. |
| Databáze: | OpenAIRE |
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