The design of cyclometalated iridium(iii )–metformin complexes for hypoxic cancer treatment
| Autor: | Qian Cao, Zong-Wan Mao, Jing Yang, Hao-Ji Fang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_element
Antineoplastic Agents Mitochondrion Iridium 010402 general chemistry 01 natural sciences Catalysis Cell Line Coordination Complexes Neoplasms Respiration Organometallic Compounds Tumor Microenvironment Materials Chemistry medicine Humans Neoplasm Metastasis Cytotoxicity Cisplatin 010405 organic chemistry Metals and Alloys General Chemistry Hypoxia (medical) Metformin 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Cancer cell Ceramics and Composites Cancer research Tumor Hypoxia medicine.symptom medicine.drug |
| Zdroj: | Chemical Communications. 57:1093-1096 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Modulating the hypoxic microenvironment is the priority for tumor treatment. Cytometalated iridium(iii)-metformin conjugates were synthesized for treating hypoxic cancer cells for the first time, which alleviate hypoxia via mitochondria respiration inhibition, thus displaying 10-fold higher cytotoxicity, emerging anti-metastasis and anti-inflammatory activities than a metformin-free Ir(iii) complex and cisplatin against hypoxic cancer cells. |
| Databáze: | OpenAIRE |
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