Single-dose live-attenuated vesicular stomatitis virus-based vaccine protects African green monkeys from Nipah virus disease
Autor: | Joseph Prescott, Elaine Haddock, Dana P. Scott, Heinz Feldmann, Blair L. DeBuysscher, Cynthia Martellaro, Donald J. Gardner, Friederike Feldmann |
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Rok vydání: | 2015 |
Předmět: |
Male
viruses Vaccines Attenuated Article Virus Microbiology Viral Envelope Proteins Cricetinae Chlorocebus aethiops Veterinary virology Vaccines DNA Animals Natural reservoir Viremia Viral shedding Glycoproteins Henipavirus Infections Immunity Cellular General Veterinary General Immunology and Microbiology biology Transmission (medicine) Vaccination Nipah Virus Public Health Environmental and Occupational Health virus diseases Outbreak Viral Vaccines Vesiculovirus Viral Load biochemical phenomena metabolism and nutrition biology.organism_classification Virology Disease Models Animal Infectious Diseases Vesicular stomatitis virus Molecular Medicine Female |
Zdroj: | Vaccine. 33:2823-2829 |
ISSN: | 0264-410X |
Popis: | Nipah virus is a zoonotic paramyxovirus that causes severe respiratory and/or encephalitic disease in humans, often resulting in death. It is transmitted from pteropus fruit bats, which serve as the natural reservoir of the virus, and outbreaks occur on an almost annual basis in Bangladesh or India. Outbreaks are small and sporadic, and several cases of human-to-human transmission have been documented as an important feature of the epidemiology of Nipah virus disease. There are no approved countermeasures to combat infection and medical intervention is supportive. We recently generated a recombinant replication-competent vesicular stomatitis virus-based vaccine that encodes a Nipah virus glycoprotein as an antigen and is highly efficacious in the hamster model of Nipah virus disease. Herein, we show that this vaccine protects African green monkeys, a well-characterized model of Nipah virus disease, from disease one month after a single intramuscular administration of the vaccine. Vaccination resulted in a rapid and strong virus-specific immune response which inhibited virus shedding and replication. This vaccine platform provides a rapid means to afford protection from Nipah virus in an outbreak situation. |
Databáze: | OpenAIRE |
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