The xmrk oncogene can escape nonfunctionalization in a highly unstable subtelomeric region of the genome of the fish xiphophorus☆
| Autor: | Jean-Nicolas Volff, Katrin Wichert, Cornelia Körting, Alexander Froschauer, Christina Schultheis, Brigitta Wilde, Jutta Duschl, Yvonne Selz, Kimberley Sweeney, Joachim Altschmied, Qingchun Zhou, Manfred Schartl |
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| Rok vydání: | 2003 |
| Předmět: |
Fish Proteins
Male X Chromosome Pseudogene Molecular Sequence Data Locus (genetics) Retrotransposon Y chromosome Cyprinodontiformes Gene Duplication Y Chromosome Gene duplication Genetics Animals Promoter Regions Genetic Gene X chromosome Repetitive Sequences Nucleic Acid Genomic Library Base Sequence biology Receptor Protein-Tyrosine Kinases Oncogenes Xiphophorus biology.organism_classification DNA Transposable Elements Hybridization Genetic Female |
| Zdroj: | Genomics. 82:470-479 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/s0888-7543(03)00168-x |
| Popis: | The Xmrk oncogene involved in melanoma formation in the fish Xiphophorus was formed relatively recently by duplication of the epidermal growth factor co-orthologue egfrb. In the platyfish X. maculatus, Xmrk is located close to the major sex-determining locus in a subtelomeric region of the X and Y sex chromosomes that frequently undergoes duplications and other rearrangements. This region accumulates repetitive sequences: more than 80% of the 33-kb region 3' of Xmrk is constituted by retrotransposable elements. The high degree of nucleotide identity between X- and Y-linked sequences and the rarity of gonosome-specific rearrangements indicated that the instability observed was not a manifestation of gonosome-specific degeneration. Seven other duplicated genes were found, all corresponding, in contrast to Xmrk, to pseudogenes (nonfunctionalization). Functional persistence of Xmrk in a highly unstable region in divergent Xiphophorus species suggests a beneficial function under certain conditions for this dispensable and potentially injurious gene. |
| Databáze: | OpenAIRE |
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