Immunoglobulin G galactosylation deficiency determined by isoelectric focusing and lectin affinoblotting in differential diagnosis of rheumatoid arthritis
| Autor: | Heidemarie Sauer, Holm Häntzschel, Kerstin Kötz, Marion Hänsler, Sylke Kaltenhäuser |
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| Rok vydání: | 1996 |
| Předmět: |
Glycosylation
Clinical Biochemistry Biochemistry Immunoglobulin G Analytical Chemistry Arthritis Rheumatoid Diagnosis Differential chemistry.chemical_compound Lectins Medicine Rheumatoid factor Humans medicine.diagnostic_test biology Isoelectric focusing business.industry Lectin Galactose medicine.disease carbohydrates (lipids) chemistry Rheumatoid arthritis Erythrocyte sedimentation rate Immunology biology.protein lipids (amino acids peptides and proteins) Differential diagnosis Isoelectric Focusing business Follow-Up Studies |
| Zdroj: | Electrophoresis. 17(3) |
| ISSN: | 0173-0835 |
| Popis: | IgG galactosylation deficiency in patients with rheumatoid arthritis (RA) can be detected by isoelectric focusing (IEF)/lectin affinoblotting. We analyzed IgG glycosylation in patients with early arthritis (n = 50) and healthy controls in order to determine the clinical value of this parameter in differential diagnosis of RA. A significant correlation between the IgG galactosylation defect at disease onset and the diagnosis of RA during the follow-up was observed. Involvement of other clinical parameters (erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor) did not improve the predictive value of IgG galactosylation changes. |
| Databáze: | OpenAIRE |
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