Tissue and serum concentrations of levofloxacin 500 mg administered intravenously or orally for antibiotic prophylaxis in biliary surgery
| Autor: | H. K. Geiss, F Klee, Stefanie Swoboda, H. von Baum, Torsten Hoppe-Tichy, K Oberdorfer |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Microbiology (medical) Ofloxacin medicine.medical_specialty medicine.medical_treatment Administration Oral Levofloxacin Gastroenterology Anti-Infective Agents Pharmacokinetics Oral administration Internal medicine Blood plasma medicine Bile Humans Cholecystectomy Pharmacology (medical) Antibiotic prophylaxis Chromatography High Pressure Liquid Etest Antibacterial agent Pharmacology Chemotherapy business.industry Gallbladder Antibiotic Prophylaxis Middle Aged Surgery Biliary Tract Surgical Procedures Spectrometry Fluorescence Infectious Diseases Injections Intravenous Female business Half-Life medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 51:459-462 |
| ISSN: | 1460-2091 |
| DOI: | 10.1093/jac/dgk056 |
| Popis: | Levofloxacin is a third-generation fluoroquinolone with a broad spectrum of antibacterial activity, comprising enterobacteria, non-fermenters, Gram-positive cocci and some anaerobic species. Members of these species are common pathogens in acute and chronic cholecystitis. This suggests that levofloxacin may be used as peri-operative prophylaxis in gall-bladder surgery. The purpose of our study was to determine serum and tissue levels of levofloxacin in cholecystectomy patients following pre-operative dosing.Patients with gall-bladder surgery were given levofloxacin 500 mg as a single dose either intravenously (iv) or orally pre-operatively, at the treating physician's decision. Gall-bladder tissue and serum samples were collected, and drug concentrations were determined by HPLC with fluorescence detection. Additionally, all tissue samples underwent routine microbiological diagnostics. MICs for aerobic isolates were determined using the Etest.A total of 61 patients (48 female, 13 male) were included. The medians of the levofloxacin concentrations in serum were 11.37 mg/L (iv) and 9.65 mg/L (oral), and in gall-bladder tissue they were 15.61 mg/kg (iv) and 17.93 mg/kg (oral). Eleven pathogens were isolated from gall-bladder samples. Post-operative wound infection was observed in two of the 61 patients.Our data suggest that levofloxacin may be considered for peri-operative prophylaxis in biliary tract surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|