Hepatic Cellular Distribution of Silica Nanoparticles by Surface Energy Modification

Autor: Sang-Joon Park, Kibeom Nam, Jin-Kyu Park, Kyu-Shik Jeong, Seong-Kyoon Choi, Su-Min Baek, Tae-Hwan Kim, A-Rang Lee, Jun-Sun Bang, Dong Yun Lee, Byeong Jun Lee, Seoung-Woo Lee
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Cell type
Kupffer Cells
Surface Properties
Phagocytosis
Context (language use)
02 engineering and technology
silica nanoparticles
Catalysis
Article
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
Drug Delivery Systems
medicine
Hepatic Stellate Cells
NP-based drug delivery
Tissue Distribution
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Liver sinusoid
Drug Carriers
Chemistry
Organic Chemistry
Endothelial Cells
General Medicine
respiratory system
021001 nanoscience & nanotechnology
Silicon Dioxide
Surface energy
Computer Science Applications
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
Liver
Drug delivery
Biophysics
Hepatic stellate cell
Hepatocytes
Surface modification
Nanoparticles
0210 nano-technology
surface energy modification
Hydrophobic and Hydrophilic Interactions
Zdroj: International Journal of Molecular Sciences
Volume 20
Issue 15
International Journal of Molecular Sciences, Vol 20, Iss 15, p 3812 (2019)
ISSN: 1422-0067
DOI: 10.3390/ijms20153812
Popis: The cellular distribution of silica nanoparticles (NPs) in the liver is not well understood. Targeting specific cells is one of the most important issues in NP-based drug delivery to improve delivery efficacy. In this context, the present study analyzed the relative cellular distribution pattern of silica NPs in the liver, and the effect of surface energy modification on NPs. Hydrophobic NP surface modification enhanced NP delivery to the liver and liver sinusoid fFendothelial cells (LSECs). Conversely, hydrophilic NP surface modification was commensurate with targeting hepatic stellate cells (HSCs) rather than other cell types. There was no notable difference in NP delivery to Kupffer cells or hepatocytes, regardless of hydrophilic or hydrophobic NP surface modification, suggesting that both the targeting of hepatocytes and evasion of phagocytosis by Kupffer cells are not associated with surface energy modification of silica NPs. This study provides useful information to target specific cell types using silica NPs, as well as to understand the relationship between NP surface energy and the NP distribution pattern in the liver, thereby helping to establish strategies for cell targeting using various NPs.
Databáze: OpenAIRE
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