Reprogramming of mitochondrial energy metabolism in malignant neoplasms
| Autor: | L V Sorokina, A A Kaplia, S V Khyzhnyak |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pyruvate dehydrogenase kinase
Apoptosis Mitochondrion malignant neoplasms medicine.disease_cause Biochemistry Antioxidants lcsh:Biochemistry Superoxide dismutase Carcinoma Lewis Lung Mice energy metabolism reprogramming Sarcoma 37 medicine Animals Humans lcsh:QD415-436 Inner mitochondrial membrane chemistry.chemical_classification Reactive oxygen species Dichloroacetic Acid biology Superoxide Dismutase Sodium Dichloroacetate sodium dichloroacetate Catalase Mitochondria Cell biology Oxidative Stress chemistry Organ Specificity Lewis lung carcinoma biology.protein Energy Metabolism Reactive Oxygen Species Reprogramming Oxidative stress mitocans |
| Zdroj: | Ukrainian Biochemical Journal, Vol 87, Iss 6, Pp 19-35 (2015) |
| ISSN: | 2409-4943 |
| Popis: | The novel ideas of fundamental role of mitochondria in the maintenance of viability of malignant cells have been reviewed. The modern state of research is considered in detail, including: mitochondrial control of the cellular redox state, sites of reactive oxygen species (ROS) production in inner mitochondrial membrane and antioxidant protection systems. Specificities of the structural-functional mitochondrial remodelling in malignant tumors, the mechanisms of the energy metabolism reprogramming, enhancement of the ROS production and adaptation to the hypoxic conditions and metabolic stress are analyzed. The available data including our research on transplanted tumors indicate that cytotoxic action of sodium dichloroacetate (the inhibitor of pyruvate dehydrogenase kinase) depends on biological properties of tumors and intensity of structural-functional mitochondrial rearrangement. Dichloroacetate turned out to be effective for sarcoma 37, but not for Lewis lung carcinoma. |
| Databáze: | OpenAIRE |
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