Comparative analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis
| Autor: | Josip Begovac, Slavko Schönwald, Margita Tomas, Jadranka Strugar, Višnja Škerk, Jacinta Vuković, Z. Strapač, Arthur Banaszak, Ivan Krhen, Renata Vrsalovic |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Antibiotics Prostatitis Chlamydia trachomatis Azithromycin medicine.disease_cause Gastroenterology Ciprofloxacin Internal medicine medicine Humans Pharmacology (medical) Chlamydiaceae Antibacterial agent Aged Gynecology Chemotherapy biology business.industry Prostate General Medicine Chlamydia Infections Middle Aged medicine.disease biology.organism_classification Infectious Diseases Chronic Disease prostatitis klamidija trahomatis azitromicin ciprofloksacin business medicine.drug |
| Popis: | A total of 89 patients, (> 18 years), with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method and/or by isolation, McCoy culture and Lugol stain in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1 x 500 mg weekly or ciprofloxacin 500 mg b.i.d. for 20 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. Significantly higher eradication (36/45: 17/44 ; P = 0.0002) and a significantly higher clinical cure (31/45: 15/44 ; P=0.0021) were achieved in the group of patients treated with azithromycin than in the ciprofloxacin group. |
| Databáze: | OpenAIRE |
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