Oxidation of hydrogen sulfide by human liver mitochondria
| Autor: | C. Vons, Abbas Abou-Hamdan, Hala Guedouari-Bounihi, Frédéric Bouillaud, Anne Lombès, N. Helmy, Carina Prip-Buus, Véronique Lenoir |
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| Přispěvatelé: | Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Sulfide Hydrogen Bioenergetics Physiology [SDV]Life Sciences [q-bio] Hydrogen sulfide Clinical Biochemistry chemistry.chemical_element Blood Pressure Mitochondria Liver Mitochondrion Models Biological Biochemistry chemistry.chemical_compound Respiration Humans Hydrogen Sulfide Obesity ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification Human liver Chemistry Substrate (chemistry) Oxidation-Reduction |
| Zdroj: | Nitric Oxide: Biology and Chemistry Nitric Oxide: Biology and Chemistry, Elsevier, 2014, 41, pp.105-112. ⟨10.1016/j.niox.2014.05.011⟩ |
| ISSN: | 1089-8603 1089-8611 |
| Popis: | Hydrogen sulfide (H2S) is the third gasotransmitter discovered. Sulfide shares with the two others (NO and CO) the same inhibiting properties towards mitochondrial respiration. However, in contrast with NO or CO, sulfide at concentrations lower than the toxic (μM) level is an hydrogen donor and a substrate for mitochondrial respiration. This is due to the activity of a sulfide quinone reductase found in a large majority of mitochondria. An ongoing study of the metabolic state of liver in obese patients allowed us to evaluate the sulfide oxidation capacity with twelve preparations of human liver mitochondria. The results indicate relatively high rates of sulfide oxidation with a large variability between individuals. These observations made with isolated mitochondria appear in agreement with the main characteristics of sulfide oxidation as established before with the help of cellular models. |
| Databáze: | OpenAIRE |
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