Short Communication: Effects of Omega-3 Fatty Acids on Triglycerides and High-Density Lipoprotein Subprofiles in HIV-Infected Persons with Hypertriglyceridemia
| Autor: | Jul Gerrior, Anu Paranandi, Jefferey Kuvin, Heidi Sheehan, Alexandra Mangili, Bela F. Asztalos, Sally Skinner, Christine Wanke, Alice M. Tang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology HIV Infections Biology Outcomes Research Placebos chemistry.chemical_compound High-density lipoprotein Double-Blind Method Virology Internal medicine Hiv infected Fatty Acids Omega-3 medicine Humans Communication effects Triglycerides Hypertriglyceridemia chemistry.chemical_classification Cross-Over Studies Triglyceride nutritional and metabolic diseases Fatty acid Middle Aged medicine.disease Crossover study Treatment Outcome Infectious Diseases Endocrinology Anti-Retroviral Agents chemistry Female lipids (amino acids peptides and proteins) Lipoproteins HDL Lipoprotein |
| Zdroj: | AIDS Research and Human Retroviruses. 30:800-805 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2014.0005 |
| Popis: | Hypertriglyceridemia and low high-density lipoprotein (HDL)-cholesterol (HDL-C) may contribute to a presumed accelerated risk for cardiovascular disease in HIV-infected individuals. We evaluated the effect of omega-3 fatty acid treatment on triglycerides, low-density lipoprotein (LDL)-C, HDL-C, and HDL subpopulations. Forty-one HIV-seropositive subjects with hypertriglyceridemia (≥150 mg/dl) on active antiretroviral therapy were enrolled in this placebo-controlled, double-blind, randomized, crossover trial comparing the effects of omega-3 fatty acid treatment (1.9 g EPA and 1.5 g DHA) on triglycerides, LDL-C, HDL-C, and HDL subpopulations. An independent sample t-test was used to assess the study start to posttreatment change for all components. After omega-3 fatty acid treatment, triglyceride levels decreased 63.2±86.9 mg/dl (p |
| Databáze: | OpenAIRE |
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