Lung cancer and cigarette smoking in women: A multicenter case-control study in Europe
| Autor: | Francesco Forastiere, Paola Zambon, Sarah C. Darby, Elise Whitley, Hermann Pohlabeln, Cristina Fortes, Carlos González, Ellen Benhamou, Lorenzo Richiardi, Karl-Heinz Jöckel, Michaela Kreuzer, Antonio Agudo, Lorenzo Simonato, Franco Merletti, Wolfgang Ahrens, Simone Benhamou, Valerie Gaborieau, Heinz Erich Wichmann, Paolo Boffetta |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Population Risk Factors Internal medicine Odds Ratio medicine Humans Risk factor education Lung cancer Aged education.field_of_study business.industry Smoking Case-control study Absolute risk reduction Odds ratio Middle Aged medicine.disease Surgery Europe Oncology Case-Control Studies Relative risk Women's Health Smoking cessation Female business |
| Zdroj: | Int. J. Cancer 88, 820-827 (2000) |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | The association between cigarette smoking and lung cancer risk in women was investigated within the framework of a case-control study in 9 centres from 6 European countries. Cases were 1,556 women up to 75 years of age with histologically confirmed primary lung cancer; 2, 450 controls with age distribution similar to cases were selected. The predominant cell type was adenocarcinoma (33.5%), with similar proportions for squamous-cell type (26.4%) and small-cell carcinoma (22.3%). Overall, smoking cigarettes at any time was associated with a 5-fold increase in lung cancer risk (odds ratio 5.21, 95% confidence interval 4.49-6.04); corresponding figures for current smoking habits were 8.94, 7.54-10.6. The association showed a dose-response relationship with duration of the habit and daily and cumulative lifetime smoking. A significant excess risk of 70% was associated with every 10 pack-years smoked. After 10 years of smoking cessation, the relative risk decreased to 20% compared to current smokers. The following characteristics were associated with a higher relative risk: inhalation of smoke, smoking non-filter cigarettes, smoking dark-type cigarettes and starting at young age. The association was observed for all major histological types, being the strongest for small-cell type carcinoma, followed by squamous-cell type and the lowest for adenocarcinoma. The proportion of lung-cancer cases in the population attributable to cigarette smoking ranged from 14% to 85%. We concluded that women share most features of the association between cigarette smoking and lung cancer observed in men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text