Erratum: Leaf Decoction of Carica papaya Combined with Artesunate Prevents Recrudescence in Plasmodium berghei-Infected Mice
| Autor: | Luigi Gradoni, Anastasia Karioti, Aldo Scalone, Luigi Messori, Stefania Orsini, Anna Rita Bilia, Carlo Severini, Anna Rosa Sannella |
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| Rok vydání: | 2019 |
| Předmět: |
Plasmodium vivax
Pharmaceutical Science Parasitemia 01 natural sciences Analytical Chemistry chemistry.chemical_compound parasitic diseases Drug Discovery medicine Plasmodium berghei Artemisinin Pharmacology biology Traditional medicine 010405 organic chemistry Organic Chemistry Plasmodium falciparum biology.organism_classification medicine.disease 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Artesunate Molecular Medicine Carica Malaria medicine.drug |
| Zdroj: | Planta Medica. |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resistant Plasmodium strains. Despite ACT has been recommended by the World Health Organization since 2001, its overall deployment in poor endemic areas is very slow, principally due to its high cost. In the malaria endemic areas, plant remedies are still widely used mostly without assurance of their efficacy and/or safety. A variety of widespread herbal drugs or natural products were already reported for their possible plasmodicidal activities, but the studies concerning their activity in combination with artemisinins are very scarce. The antimalarial activity of papaya is mostly anecdotal, and the present study is aimed at investigating the antiplasmodial activity of a decoction obtained by traditional recipe from the mature leaves of Carica papaya. The decoction was analyzed by HPLC-DAD-MS (high performance liquid chromatography coupled with diodoarray detector and mass spectrometry) showing the presence of caffeoyl derivatives and di- and triglycosides of flavonols. The extract was found to be active against P. falciparum 3D7 strains with a synergism in the presence of artemisinin. In vivo activity against the murine malaria model of Plasmodium berghei was disclosed both for the dried extract alone (250, 500, and 750 mg/kg/d) and for its combination with artesunate (250 mg/kg/d papaya plus 10 mg/kg/d artesunate). This combination displayed the greatest antimalarial activity in terms of reduction of parasitemia and prevention of recrudescence in animals recovered from the infection. |
| Databáze: | OpenAIRE |
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