Sex differences in the longitudinal associations between body composition and bone stiffness index in European children and adolescents
Autor: | Charalambos Chadjigeorgiou, Lan Cheng, Paola Russo, Stefaan De Henauw, Luis A. Moreno, Hermann Pohlabeln, Dénes Molnár, Angie S Page, Gabrielle Eiben, Antje Hebestreit, Toomas Veidebaum, Wolfgang Ahrens |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Percentile Longitudinal study Index (economics) Histology Adolescent Physiology Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Negative association Body composition Pediatrics Body Mass Index 03 medical and health sciences 0302 clinical medicine Fat free mass Linear regression Sex differences Medicine Humans Child Exercise Orthodontics Sex Characteristics business.industry General Medicine Composition (combinatorics) Bone stiffness index Quantitative ultrasound 030104 developmental biology Menarche Body Composition PediatricsBody compositionBone stiffness indexSex differencesLongitudinal study Female Sedentary Behavior SPS Exercise Nutrition and Health Sciences Bone stiffness business Demography |
Zdroj: | Cheng, L, Pohlabeln, H, Ahrens, W, Russo, P, Veidebaum, T, Chadjigeorgiou, C, Molnar, D, Eiben, G, De Henauw, S, Moreno, L, Page, A & Hebestreit, A 2020, ' Sex differences in the longitudinal associations between body composition and bone stiffness index in European children and adolescents ', Bone, vol. 131, 115162 . https://doi.org/10.1016/j.bone.2019.115162 Bone, 131:115162 Bone (New York, NY) 131 (2019): 115162. doi:10.1016/j.bone.2019.115162 info:cnr-pdr/source/autori:Cheng L, Pohlabeln H, Ahrens W, Russo P, Veidebaum T, Chadjigeorgiou C, Molnár D, Eiben G, De Henauw S, Moreno L, Page A, Hebestreit A; IDEFICS and I.Family Consortia./titolo:Sex differences in the longitudinal associations between body composition and bone stiffness index in European children and adolescents./doi:10.1016%2Fj.bone.2019.115162/rivista:Bone (New York, NY)/anno:2019/pagina_da:115162/pagina_a:/intervallo_pagine:115162/volume:131 |
Popis: | Fat mass (FM) and fat free mass (FFM) may influence bone health differentially. However, existing evidences on associations between FM, FFM and bone health are inconsistent and vary according to sex and maturity. The present study aims to evaluate longitudinal associations between FM, FFM and bone stiffness index (SI) among European children and adolescents with 6 years follow-up. A sample of 2468 children from the IDEFICS/I.Family was included, with repeated measurements of SI using calcaneal quantitative ultrasound, body composition using skinfold thickness, sedentary behaviors and physical activity using self-administrated questionnaires. Regression coefficients (β) and 99%-confidence intervals (99% CI) were calculated by sex-specified generalized linear mixed effects models to analyze the longitudinal associations between FM and FFM z-scores (zFM and zFFM) and SI percentiles, and to explore the possible interactions between zFM, zFFM and maturity. Baseline zFFM was observed to predict the change in SI percentiles in both boys (β = 4.57, 99% CI: 1.36, 7.78) and girls (β = 3.42, 99% CI: 0.05, 6.79) after 2 years. Moreover, baseline zFFM (β = 8.72, 99% CI: 3.18, 14.27 in boys and β = 5.89, 99% CI: 0.34, 11.44 in girls) and the change in zFFM (β = 6.58, 99% CI: 0.83, 12.34 in boys and β = 4.81, 99% CI: −0.41, 10.02 in girls) were positively associated with the change in SI percentiles after 6 years. In contrast, a negative association was observed between the change in zFM and SI percentiles in boys after 6 years (β = −3.70, 99% CI: −6.99, −0.42). Besides, an interaction was observed between the change in zFM and menarche on the change in SI percentiles in girls at 6 years follow-up (p = .009), suggesting a negative association before menarche while a positive association after menarche. Our findings support the existing evidences for a positive relationship between FFM and SI during growth. Furthermore, long-term FM gain was inversely associated with SI in boys, whereas opposing associations were observed across menarche in girls. |
Databáze: | OpenAIRE |
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