Is the Remarkable Contradiction between Histology and 14C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14C Urea Breath Test?
| Autor: | Yavuz Narin, Yusuf Yazgan, A.M. Özel, Ahmet Kemal Gürbüz, Levent Demirtürk, Hüseyin Baloğlu |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Urea breath test Rapid urease test 030204 cardiovascular system & hematology Sensitivity and Specificity Biochemistry Gastroenterology Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Positive predicative value Internal medicine Biopsy Humans Urea Medicine False Positive Reactions Carbon Radioisotopes Prospective Studies Stomach Ulcer False Negative Reactions Aged Helicobacter pylori medicine.diagnostic_test biology business.industry Biochemistry (medical) Histology Cell Biology General Medicine Middle Aged biology.organism_classification Breath Tests 030220 oncology & carcinogenesis Predictive value of tests Female business |
| Zdroj: | Journal of International Medical Research. 33:632-640 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000503300604 |
| Popis: | We assessed the diagnostic value of the 14C urea breath test (UBT) in the detection of Helicobacter pylori compared with histology and the rapid urease test (RUT). The study included 68 patients (22 men and 46 women) with dyspeptic symptoms. H. pylori status was evaluated by 14C UBT, RUT and histology. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were determined for 14C UBT and for RUT. Histology revealed dense yeast-like micro-organisms in the biopsy specimens in all patients with false-positive results by 14C UBT (n = 8), a significantly higher proportion than in patients with negative 14C UBT (five of 31). The low specificity of the H. pylori14C UBT should not be neglected by accepting histology results as false-negative. Gastric mucosal colonization by yeast-like micro-organisms with urease activity can account for the high frequency of false-positive results for 14C UBT. |
| Databáze: | OpenAIRE |
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