Effect of Concanavalin A on Intracellular K+ and Na+ Concentration and K+ Transport of Human Lymphocytes
| Autor: | T. Günther, R. Averdunk |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
ATPase
Immunology Stimulation Concanavalin A Membrane fluidity Humans Immunology and Allergy Lymphocytes Na+/K+-ATPase Ouabain Binding Sites biology Chemistry Osmolar Concentration Sodium Inulin Biological Transport Hematology Biochemistry Permeability (electromagnetism) Potassium biology.protein Biophysics Extracellular Space Flux (metabolism) Intracellular |
| Zdroj: | Immunobiology. 157:132-144 |
| ISSN: | 0171-2985 |
| Popis: | Incubation of human lymphocytes with ConA causes an increase in [Na + ]; and a decrease in [K + ];. This effect is not due to the experimental washing procedure, but is due to the ConAinduced increase in permeability which is not fully compensated by the increase in active transport. The ConA-induced increase in 42 K + uptake consists of an increase in leak flux which is independent of [Na + ] o , and of an increase in pump flux which is dependent on [Na + ] 0 . The increase in leak flux may be caused by increased membrane fluidity. The increase in pump flux may be produced by the increased [Na + ]. and by a stimulation of Na + , K + ATPase. |
| Databáze: | OpenAIRE |
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