Comprehensive clinical profiling of the Gauting locoregional lung adenocarcinoma donors

Autor: Serge Guyétant, Jürgen Behr, Yves Courty, Kristina A. M. Arendt, Agnès Petit-Courty, Sylvain Marchand-Adam, Valérie Gissot, Anne-Sophie Lamort, Ina Koch, Jan‐Christian Kaiser, Georgios T. Stathopoulos, Ioanna Giopanou, Maria Oplopoiou, Michael Lindner, Ioannis Lilis, Martin E. Eichhorn, Rudolf Hatz, Giannoula Ntaliarda, Mario A.A. Pepe, Laura V. Klotz, Anja Stowasser, Alicia Morresi-Hauf, Sabine J. Behrend
Přispěvatelé: Ludwig Maximilians University of Munich, German Center for Lung Research, Comprehensive pneumology center, Partenaires INRAE, University Hospital, German Centre for Lung Research, Institut National de la Santé et de la Recherche Médicale (INSERM), University-Hospital Munich-Großhadern [München], Heidelberg University, University of Patras, Alexander Fleming Biomedical Sciences Research Center, Asklepios Medical Center, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Centre Hospitalier Régional Universitaire de Tours (CHRU de Tours), Asklepios Lung Clinic Gauting, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Ludwig-Maximilians University [Munich] (LMU), ProdInra, Migration
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Research design
Male
Cancer Research
Lung Neoplasms
Death risk
Pneumologie et système respiratoire
LADC
lung adenocarcinoma
obstruction
smoking
survival
Pulmonary Surgical Procedures
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
0302 clinical medicine
Recurrence
Germany
Medicine
Prospective Studies
Cancer
Original Research
Curative intent
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
résection
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cohort
Adenocarcinoma
Female
Lung resection
medicine.medical_specialty
adénocarcinome
Médecine humaine et pathologie
[SDV.CAN]Life Sciences [q-bio]/Cancer
Adenocarcinoma of Lung
lcsh:RC254-282
Time-to-Treatment
03 medical and health sciences
FEV1/FVC ratio
[SDV.CAN] Life Sciences [q-bio]/Cancer
Internal medicine
Humans
tabagisme
Radiology
Nuclear Medicine and imaging
Mortality
Pulmonology and respiratory tract
Aged
Neoplasm Staging
Lung
business.industry
Clinical Cancer Research
medicine.disease
030104 developmental biology
poumon
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Human health and pathology
Ladc
Lung Adenocarcinoma
Obstruction
Smoking
Survival
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Cancer Medicine
Cancer Medicine, Vol 8, Iss 4, Pp 1486-1499 (2019)
Cancer Medicine, Wiley, 2019, 8 (4), pp.1486-1499. ⟨10.1002/cam4.2031⟩
Cancer Med. 8, 1486-1499 (2019)
Cancer Medicine (8), 1486-1499. (2019)
Cancer Medicine, 2019, 8 (4), pp.1486-1499. ⟨10.1002/cam4.2031⟩
ISSN: 2045-7634
DOI: 10.1002/cam4.2031⟩
Popis: International audience; A comprehensive characterization of lung adenocarcinoma (LADC) clinical features is currently missing. We prospectively evaluated Caucasian patients with early-stage LADC. Patients with LADC diagnosed between 2011 and 2015 were prospectively assessed for lung resection with curative intent. Fifty clinical, pathologic, radiologic, and molecular variables were recorded. Patients were followed till death/study conclusion. The main findings were compared to a separate cohort from France. Of 1943 patients evaluated, 366 were enrolled (18.8%; 181 female; 75 never-smokers; 28% of registered Bavarian cases over the study period). Smoking and obstruction were significantly more prevalent in GLAD compared with adult Bavarians (P < 0.0001). Ever-smoker tumors were preferentially localized to the upper lobes. We observed 120 relapses and 74 deaths over 704 cumulative follow-up years. Median overall and disease-free survival were >7.5 and 3.6 years, respectively. Patients aged 65 years, resected >60 days postdiagnosis, with abnormal FVC/DLCO VA , N2/N3 stage, or solid histology had significantly decreased survival estimates. These were fit into a weighted locoregional LADC death risk score that outperformed pTNM7 in predicting survival in the GLAD and in our second cohort. We define the clinical gestalt of locoregional LADC and provide a new clinical tool to predict survival, findings that may aid future management and research design
Databáze: OpenAIRE
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