Discordant lymphoma: MALT lymphoma of the stomach and follicular lymphoma of the parotid gland
| Autor: | Shigeru Tomoyasu, Kazuhiro Kaneko, Hidekazu Ota, Tsuyoshi Nakamaki, Hiroshi Ishii, Miki Kushima, Toshiko Yamochi-Onizuka, Eisuke Shiozawa, Mitsunori Hoshino, Yutsuki Yamamoto, Mitsuo Kusano, Keiji Mitamura |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Follicular lymphoma Pathology and Forensic Medicine Neoplasms Multiple Primary Stomach Neoplasms immune system diseases hemic and lymphatic diseases medicine Humans Lymphoma Follicular Gene Rearrangement biology business.industry Stomach MALT lymphoma Lymphoma B-Cell Marginal Zone General Medicine Gene rearrangement Middle Aged Helicobacter pylori medicine.disease biology.organism_classification Magnetic Resonance Imaging digestive system diseases Genes bcl-2 Parotid Neoplasms Lymphoma Parotid gland Lymphatic system medicine.anatomical_structure Female Immunoglobulin Heavy Chains Tomography X-Ray Computed business |
| Zdroj: | Pathology International. 53:557-562 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1046/j.1440-1827.2003.01506.x |
| Popis: | More than one histological type of malignant lymphoma can occur simultaneously in an individual. The entity is classified as either composite or discordant lymphoma. Both types of lymphoma, particularly discordant lymphoma comprised of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT-L) and follicular lymphoma (FL), are rare. We report a case of discordant lymphoma comprising MALT-L in the stomach and FL in the parotid gland. The patient was a 50-year-old Japanese woman who visited the University Hospital of Showa (Tokyo, Japan) because a barium study showed erosive gastric lesions. A gastro-intestinal endoscopy was performed 2 months after the barium study, which showed irregular erosions throughout the stomach body. A gastric biopsy showed MALT-L, and Helicobacter pylori (H. pylori) infection was confirmed. The patient had noticed a painless and elastic hard tumor mass of about 2 cm in diameter in the area of the left parotid gland 6 months before the barium study. We removed the parotid gland tumor and diagnosed it as FL 6 months after the barium study. We were able to diagnose the MALT-L and FL by morphological, immunohistochemical and molecular analyses of paraffin-embedded sections. This appears to be the first reported case of MALT-L and FL occurring together as a discordant lymphoma. |
| Databáze: | OpenAIRE |
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