Differential susceptibility in youth: Evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'
| Autor: | Andrew Smolen, John R. Z. Abela, Jessica L. Jenness, Esther Nederhof, Caroline W. Oppenheimer, Albertine J. Oldehinkel, Benjamin L. Hankin, Johan Ormel, Jami F. Young |
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| Přispěvatelé: | Science in Healthy Ageing & healthcaRE (SHARE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
5-HTTLPR DEPRESSIVE SYMPTOMATOLOGY Developmental psychology Cohort Studies 0302 clinical medicine parenting Behavioral inhibition Parent-Child Relations Child GENE-ENVIRONMENT INTERACTION Serotonin Plasma Membrane Transport Proteins 05 social sciences Positive parenting Psychiatry and Mental health Schizophrenia differential susceptibility EMOTION-REGULATION behavior and behavior mechanisms Female Original Article Psychology MENTAL-HEALTH psychological phenomena and processes 050104 developmental & child psychology Clinical psychology ADOLESCENT DEPRESSION Adult Adolescent Genotype DIATHESIS-STRESS GxE 03 medical and health sciences Cellular and Molecular Neuroscience TRANSPORTER PROMOTER POLYMORPHISM mental disorders medicine Humans Genetic Predisposition to Disease 0501 psychology and cognitive sciences Alleles Biological Psychiatry positive emotion medicine.disease Mental health Diathesis–stress model Affect BEHAVIORAL-INHIBITION SEROTONIN TRANSPORTER Behavioral medicine Positive emotion 030217 neurology & neurosurgery FAMILY ENVIRONMENT |
| Zdroj: | Translational Psychiatry, 1:44. Nature Publishing Group Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | Positive affect has been implicated in the phenomenological experience of various psychiatric disorders, vulnerability to develop psychopathology and overall socio-emotional functioning. However, developmental influences that may contribute to positive affect have been understudied. Here, we studied youths' 5-HTTLPR genotype and rearing environment (degree of positive and supportive parenting) to investigate the differential susceptibility hypothesis (DSH) that youth carrying short alleles of 5-HTTLPR would be more influenced and responsive to supportive and unsupportive parenting, and would exhibit higher and lower positive affect, respectively. Three independent studies tested this gene-environment interaction (GxE) in children and adolescents (age range 9-15 years; total N = 1874). In study 1 (N = 307; 54% girls), positive/supportive parenting was assessed via parent report, in study 2 (N = 197; 58% girls) via coded observations of parent-child interactions in the laboratory and in study 3 (N = 1370; 53% girls) via self report. Results from all the three studies showed that youth homozygous for the functional short allele of 5-HTTLPR were more responsive to parenting as environmental context in a 'for better and worse' manner. Specifically, the genetically susceptible youth (that is, S'S' group) who experienced unsupportive, non-positive parenting exhibited low levels of positive affect, whereas higher levels of positive affect were reported by genetically susceptible youth under supportive and positive parenting conditions. These GxE findings are consistent with the DSH and may inform etiological models and interventions in developmental psychopathology focused on positive emotion, parenting and genetic susceptibility. Translational Psychiatry (2011) 1, e44; doi:10.1038/tp.2011.44; published online 4 October 2011 |
| Databáze: | OpenAIRE |
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