Polylactide-based microspheres prepared using solid-state copolymerized chitosan and d , l -lactide
| Autor: | A. N. Zelenetskii, Tatiana A. Akopova, Ch. Grandfils, Tatiana S. Demina, L. V. Vladimirov, Elena Markvicheva |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polyesters Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Dioxanes Biomaterials Chitosan chemistry.chemical_compound Amphiphile Polymer chemistry Copolymer Microparticle Microbead (research) 021001 nanoscience & nanotechnology Evaporation (deposition) Microspheres 0104 chemical sciences Polyester Chemical engineering chemistry Mechanics of Materials Emulsion 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 59:333-338 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2015.09.094 |
| Popis: | Amphiphilic chitosan-g-poly(d,l-lactide) copolymers have been manufactured via solid-state mechanochemical copolymerization and tailored to design polyester-based microspheres for tissue engineering. A single-step solid-state reactive blending (SSRB) using low-temperature co-extrusion has been used to prepare these copolymers. These materials have been valorized to stabilize microspheres processed by an oil/water emulsion evaporation technique. Introduction of the copolymers either in water or in the oil phase of the emulsion allowed to replace a non-degradable emulsifier typically used for microparticle preparation. To enhance cell adhesion, these copolymers were also tailored to bring amino-saccharide positively charged segments to the microbead surface. Size distribution, surface morphology, and total microparticle yield have been studied and optimized as a function of the copolymer composition. |
| Databáze: | OpenAIRE |
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