Longitudinal neutralization activities on authentic Omicron variant provided by three doses of BBIBP‐CorV vaccination during one year

Autor: Dan‐yun Lai, Jun‐biao Xue, Ping He, He‐wei Jiang, Yang Li, Ming‐liang Ma, Wei Hong, Jun‐ping Yu, Hong‐ping Wei, Sheng‐ce Tao
Rok vydání: 2022
Předmět:
Zdroj: PROTEOMICS. 23:2200306
ISSN: 1615-9861
1615-9853
DOI: 10.1002/pmic.202200306
Popis: The majority of people in China have been immunized with the inactivated viral vaccine BBIBP-CorV. The emergence of the Omicron variant raised the concerns about protection efficacy of the inactivated viral vaccine in China. However, longitudinal neutralization data describing protection efficacy against Omicron variant is still lacking. Here we present one-year longitudinal neutralization data of BBIBP-CorV on authentic Omicron, Delta, and wild-type strains using 224 sera collected from 14 volunteers who have finished three doses BBIBP-CorV. The sera were also subjected for monitoring the SARS-CoV-2 specific IgG, IgA, and IgM responses on protein and peptide microarrays. The neutralization titers showed different protection efficacies against the three strains. By incorporating IgG and IgA signals of proteins and Spike protein derived peptide on microarray, panels as potential surrogate biomarkers for rapid estimation of neutralization titers were established. These data support the necessity of the 3
Databáze: OpenAIRE
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