Effects of acute psychosocial stress on working memory related brain activity in men
| Autor: | Oliver T. Wolf, Riklef Weerda, Markus Muehlhan, Christiane M. Thiel |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Brain activity and meditation Effects of stress on memory Hippocampus Hippocampal formation Young Adult Image Interpretation Computer-Assisted Reaction Time Trier social stress test medicine Humans Radiology Nuclear Medicine and imaging Prefrontal cortex Research Articles Brain Mapping Radiological and Ultrasound Technology medicine.diagnostic_test Working memory Brain Magnetic Resonance Imaging Memory Short-Term Neurology Neurology (clinical) Anatomy Psychology Functional magnetic resonance imaging Neuroscience Stress Psychological |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1065-9471 |
| Popis: | r Abstract: Acute psychosocial stress in humans triggers the release of glucocorticoids (GCs) and influ- ences performance in declarative and working memory (WM) tasks. These memory systems rely on the hippocampus and prefrontal cortex (PFC), where GC-binding receptors are present. Previous stud- ies revealed contradictory results regarding effects of acute stress on WM-related brain activity. We combined functional magnetic resonance imaging with a standardized psychosocial stress protocol to investigate the effects of acute mental stress on brain activity during encoding, maintenance, and re- trieval of WM. Participants (41 healthy young men) underwent either a stress or a control procedure before performing a WM task. Stress increased salivary cortisol levels and tended to increase WM ac- curacy. Neurally, stress-induced increases in cortical activity were evident in PFC and posterior parie- tal cortex (PPC) during WM maintenance. Furthermore, hippocampal activity was modulated by stress during encoding and retrieval with increases in the right anterior hippocampus during WM encoding and decreases in the left posterior hippocampus during retrieval. Our study demonstrates that stress increases activity in PFC and PPC specifically during maintenance of items in WM, whereas effects on hippocampal activity are restricted to encoding and retrieval. The finding that psychosocial stress can increase and decrease activity in two different hippocampal areas may be relevant for understanding the often-reported phase-dependent opposing behavioral effects of stress on long-term memory. Hum Brain Mapp 00:000-000, 2010. V C 2010 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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