Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing
| Autor: | Junwei Zhang, Juan Liu, Ruijuan Yao, Tao Gao, Nihui Zhang, Yao Wang, Fang Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cicatrix
Hypertrophic macromolecular substances 02 engineering and technology Matrix metalloproteinase Pharmacology Biochemistry Aloe vera Rats Sprague-Dawley Chitosan 03 medical and health sciences chemistry.chemical_compound Hypertrophic scar Structural Biology In vivo Cations medicine Animals Humans Iridoids Molecular Biology Cells Cultured 030304 developmental biology Wound Healing 0303 health sciences integumentary system biology Chemistry technology industry and agriculture Hydrogels General Medicine 021001 nanoscience & nanotechnology biology.organism_classification medicine.disease Bandages Rats Self-healing hydrogels Genipin Female Plant Preparations 0210 nano-technology Wound healing |
| Zdroj: | International Journal of Biological Macromolecules. 154:835-843 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2020.03.161 |
| Popis: | It is of great clinical significance to design wound dressing materials with combined excellent wound healing properties and superior capability to suppress hypertrophic scar formation. This study aimed to examine if and how the cationicity of chitosan would affect the hypertrophic scar-related outcomes, through preparing carboxymethyl chitosan hydrogels with different genipin concentrations (2.5%, 5%, 10% and 15%, respectively). An optimum window of chitosan cationicity (5% in our case) demonstrated potential to mitigate hypertrophic scar in wound healing by suppressing the expression of a-smooth muscle actin (a-SMA) and promoting secretion of type I matrix metalloproteinases (MMP-1). In vivo, the CMCS-5% hydrogel again showed smaller, thinner and smoother wound appearance. Moreover, the CMCS-5% sample with additional incorporation of 2% (V/V) Aloe vera gel exhibited further improved performance in scar inhibition. Overall, such findings might have important implications in chitosan-based wound dressing design for high-quality wound repair and effective scar inhibition. |
| Databáze: | OpenAIRE |
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