Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery

Autor: Liliana Werner, Colby Gerhart, Victoria Scheinfeld, Nick Mamalis, Arturo Bravo-Nuevo, Colleen Withers, Robert C. Getts, Paul G. FitzGerald, Mindy George-Weinstein, Jacquelyn Gerhart
Rok vydání: 2018
Předmět:
0301 basic medicine
Fibrillin-1
Fluorescent Antibody Technique
Medical Biochemistry and Metabolomics
Inbred C57BL
Ophthalmology & Optometry
Lens
Mice
Myosin
Fluorescent Antibody Technique
Indirect
Myofibroblasts
Myo/Nog cells
Zonule
Anatomy
Sensory Systems
Zonule of Zinn
medicine.anatomical_structure
Lens (anatomy)
lipids (amino acids
peptides
and proteins)
Female
Rabbits
Indirect
Ciliary body
Biology
Myosins
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
Ciliary processes
Opthalmology and Optometry
Lens
Crystalline
medicine
Animals
Humans
Vimentin
Noggin
Eye Disease and Disorders of Vision
MyoD Protein
Retina
Ligaments
Phacoemulsification
Crystalline
Ciliary Body
Neurosciences
Skeletal muscle
Capsule Opacification
Actins
carbohydrates (lipids)
Mice
Inbred C57BL
Ophthalmology
030104 developmental biology
Posterior Capsule of the Lens
Posterior capsule opacification
Carrier Proteins
Popis: Myo/Nog cells, named for their expression of MyoD and noggin, enter the eye during early stages of embryonic development. Their release of noggin is critical for normal morphogenesis of the lens and retina. Myo/Nog cells are also present in adult eyes. Single nucleated skeletal muscle cells designated as myofibroblasts arise from Myo/Nog cells in cultures of lens tissue. In this report we document the presence of Myo/Nog cells in the lens, ciliary body and on the zonule of Zinn in mice, rabbits and humans. Myo/Nog cells were rare in all three structures. Their prevalence increased in the lens and ciliary body of rabbits 24 h following cataract surgery. Rabbits developed posterior capsule opacification (PCO) within one month of surgery. The number of Myo/Nog cells continued to be elevated in the lens and ciliary body. Myo/Nog cells containing alpha smooth muscle actin and striated muscle myosin were present on the posterior capsule and overlaid deformations in the capsule. Myo/Nog cells also were present on the zonule fibers and external surface of the posterior capsule. These findings suggest that Myo/Nog contribute to PCO and may use the zonule fibers to migrate between the ciliary processes and lens.
Databáze: OpenAIRE
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