Autor: |
Harry B. Marr, Kevin P. Madauss, Jonathan Y. Bass, Shawn P. Williams, Dan Todd, Paul Kenneth Spearing, Adwoa Akwabi-Ameyaw, Lihong Chen, Robert B. McFadyen, Justin A. Caravella, Derek J. Parks, Frank Navas, David N. Deaton, Katrina L. Creech, G. Bruce Wisely, Richard Dana Caldwell, Aaron B. Miller |
Rok vydání: |
2009 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 19:4733-4739 |
ISSN: |
0960-894X |
Popis: |
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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