Rare Helicobacter pylori Virulence Genotypes in Bhutan
| Autor: | Muhammad Miftahussurur, Thawee Ratanachu-ek, Varocha Mahachai, Yoshio Yamaoka, Seiji Shiota, Osamu Matsunari, Tomohisa Uchida, Rumiko Suzuki, Lotay Tshering, Ratha-Korn Vilaichone |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Genotype Atrophic gastritis Population Virulence Article Young Adult 03 medical and health sciences Bacterial Proteins medicine Humans CagA Amino Acid Sequence Bhutan education Aged Aged 80 and over Antigens Bacterial education.field_of_study Multidisciplinary Helicobacter pylori biology Incidence (epidemiology) Cancer Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Virology 3. Good health 030104 developmental biology Female |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Both the prevalence of Helicobacter pylori infection and the incidence of gastric cancer are high in Bhutan. The high incidence of atrophic gastritis and gastric cancer suggest the phylogeographic origin of an infection with a more virulent strain of H. pylori. More than 90% of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the most virulent type of vacA (s1 type). More than half also had multiple repeats in East Asian-type CagA, which are rare in other countries and are reported characteristictly found in assciation with atrophic gastritis and gastric cancer consistent with Bhutanese strains having multiple H. pylori virulence factors associated with an increase in gastric cancer risk. Phylogeographic analyses showed that most Bhutanese strains belonged to the East Asian population type with some strains (17.5%) sharing East Asian and Amerindian components. Only 9.5% belonged to the European type consistant with H. pylori in Bhutan representing an intermediate evolutionary stage between H. pylori from European and East Asian countries. |
| Databáze: | OpenAIRE |
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