The Cell Surface Markers Expression in Postmenopausal Women and Relation to Obesity and Bone Status
Autor: | Eva Jahnova, Mira Horvathova, Viera Spustova, Michaela Szabova, Silvia Ilavska, Stefíková K, Jana Tulinska, Martin Gajdoš, Zora Krivošíková |
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Rok vydání: | 2017 |
Předmět: |
Adult
0301 basic medicine obesity medicine.medical_specialty Myeloid cell surface molecules T-Lymphocytes Health Toxicology and Mutagenesis Osteoporosis lcsh:Medicine postmenopausal women Inflammation bone status Systemic inflammation Article 03 medical and health sciences 0302 clinical medicine Immune system Bone Density Internal medicine medicine Humans Osteoporosis Postmenopausal Aged B-Lymphocytes Cluster of differentiation business.industry lcsh:R Public Health Environmental and Occupational Health Middle Aged medicine.disease Postmenopause Menopause 030104 developmental biology Endocrinology medicine.anatomical_structure inflammation 030220 oncology & carcinogenesis Female medicine.symptom business Body mass index Biomarkers |
Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 14; Issue 7; Pages: 751 International Journal of Environmental Research and Public Health, Vol 14, Iss 7, p 751 (2017) |
ISSN: | 1660-4601 |
Popis: | The age-related changes and hormonal deprivation in postmenopausal women are associated with the immune response alteration. The excessive fat accumulation, local and systemic inflammation may lead to dysregulation in immune function and relevant health problems, including obesity and osteoporosis. We analyzed the expression of cell surface markers in the venous blood specimens, stained with fluorophores-conjugated monoclonal antibodies and analysed by multicolour flow cytometry. The significant changes of cytotoxic, naive, and memory T-lymphocytes, plasmacytoid dendritic cells (DCs) were in postmenopausal women versus fertile women. Body mass index (BMI) affected markedly the cell surface expression of CD265/RANK. Osteoporosis is linked to reduced percentage of plasmacytoid DCs, and elevated natural Treg cells (p < 0.05). The confounding factors such as women age, BMI, bone mineral density (BMD), waist size and tissue fat affect the expression of RANK on myeloid DCs and CD40L on T-lymphocytes that might be the immunophenotypic modulators after menopause. |
Databáze: | OpenAIRE |
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