Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2,4-dione derivatives: Histone deacetylases inhibitory activity and molecular docking study

Autor:	Abdelrahman Hamdi, Walaa M. Elhusseiny, Dina I.A. Othman, Abdullah Haikal, Ahmed H. Bakheit, Adel S. El-Azab, Mohamed H.M. Al-Agamy, Alaa A.-M. Abdel-Aziz
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Antineoplastic Agents Apoptosis General Medicine Histone Deacetylases Molecular Docking Simulation Histone Deacetylase Inhibitors Structure-Activity Relationship Drug Design Cell Line Tumor Drug Discovery Drug Screening Assays Antitumor Cell Proliferation
Zdroj:	European Journal of Medicinal Chemistry. 244:114827
ISSN:	0223-5234
Popis:	The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2,4-dione derivatives 18a-f and 19a-f was investigated, compared to doxorubicin (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537c6a78be43367d886ec38f0d385531 https://doi.org/10.1016/j.ejmech.2022.114827 Zobrazit plný text záznamu Full Text from ScienceDirect