The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries
| Autor: | Megan E Carey, Jin Kyung Park, Peter Aaby, Biruk Yeshitela, Aissatou Niang, Muna Ahmed El Tayeb, Robert F. Breiman, Morten Bjerregaard-Andersen, Arvinda Sooka, Vera von Kalckreuth, Beatrice Olack, Tsiriniaina Jean Luco Razafindrabe, Mekonnen Teferi, Ellis Owusu-Dabo, Se Eun Park, Ligia Maria Cruz Espinoza, Amy Gassama, Nagla Gasmelseed, Raphaël Rakotozandrindrainy, Ursula Panzner, Yaw Adu-Sarkodie, Tiana Mirana Raminosoa, Karen H. Keddy, Anna Jaeger, Barry S. Fields, Gordon Dougan, Heidi Schütt-Gerowitt, Nimako Sarpong, Frank Konings, Abdramane Bassiahi Soura, Emmanuel Sampo, Denise Dekker, Stephen Baker, Florian Marks, Jessica Fung Deerin, Jürgen May, Julian T. Hertz, Mohammad Ali, Sandra Van Puyvelde, Adama Tall, John D. Clemens, Duy Thanh Pham, John A. Crump, Holly M. Biggs, Leonard Cosmas, Ralf Krumkamp, Abraham Aseffa, Leon Parfait Kabore, Ondari D. Mogeni, Sandra Valborg Løfberg, Justin Im, Joel M. Montgomery, Gi Deok Pak |
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| Přispěvatelé: | Park, Se Eun [0000-0002-1632-3045], Crump, John A [0000-0002-4529-102X], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Salmonella typhimurium
0301 basic medicine Serotype Medicine (General) Salmonella medicine.medical_specialty medical microbiology Salmonella enteritidis 030106 microbiology Population Context (language use) Infectious and parasitic diseases RC109-216 Biology medicine.disease_cause cross-sectional survey 03 medical and health sciences R5-920 Medical microbiology Antibiotic resistance medicine Humans Child education Phylogeny education.field_of_study Transmission (medicine) Original research Health Policy Public Health Environmental and Occupational Health Genomics biochemical phenomena metabolism and nutrition Kenya Virology 030104 developmental biology Pharmaceutical Preparations epidemiology Human medicine typhoid and paratyphoid fevers |
| Zdroj: | BMJ Global Health BMJ Global Health, Vol 6, Iss 8 (2021) |
| ISSN: | 2059-7908 |
| DOI: | 10.1136/bmjgh-2021-005659 |
| Popis: | Funder: Swedish International Development Cooperation Agency (SIDA) Funder: Government of Republic of Korea Funder: US Centers for Disease Control and Prevention Background: Invasive non-typhoidal Salmonella (iNTS) is one of the leading causes of bacteraemia in sub-Saharan Africa. We aimed to provide a better understanding of the genetic characteristics and transmission patterns associated with multi-drug resistant (MDR) iNTS serovars across the continent. Methods: A total of 166 iNTS isolates collected from a multi-centre surveillance in 10 African countries (2010–2014) and a fever study in Ghana (2007–2009) were genome sequenced to investigate the geographical distribution, antimicrobial genetic determinants and population structure of iNTS serotypes–genotypes. Phylogenetic analyses were conducted in the context of the existing genomic frameworks for various iNTS serovars. Population-based incidence of MDR-iNTS disease was estimated in each study site. Results: Salmonella Typhimurium sequence-type (ST) 313 and Salmonella Enteritidis ST11 were predominant, and both exhibited high frequencies of MDR; Salmonella Dublin ST10 was identified in West Africa only. Mutations in the gyrA gene (fluoroquinolone resistance) were identified in S. Enteritidis and S. Typhimurium in Ghana; an ST313 isolate carrying blaCTX-M-15 was found in Kenya. International transmission of MDR ST313 (lineage II) and MDR ST11 (West African clade) was observed between Ghana and neighbouring West African countries. The incidence of MDR-iNTS disease exceeded 100/100 000 person-years-of-observation in children aged |
| Databáze: | OpenAIRE |
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