Safety and influence of a novel extract of fenugreek on healthy young women: a randomized, double-blinded, placebo-controlled study
| Autor: | Jestin V Thomas, Febi John, Krishnakumar Im, Balu Maliakel, Aman Khanna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Trigonella Fenugreek Placebo-controlled study Physiology Placebo Menopausal rating scale 03 medical and health sciences 0302 clinical medicine Diabetes mellitus medicine Women Trigonella foenum-graecum Adverse effect Testosterone General Environmental Science biology business.industry RX1-681 Homeopathy biology.organism_classification medicine.disease Irritability 030104 developmental biology 030220 oncology & carcinogenesis General Earth and Planetary Sciences Medicine Amenorrhea medicine.symptom business Sexual problems Hormone |
| Zdroj: | Clinical Phytoscience, Vol 7, Iss 1, Pp 1-12 (2021) |
| ISSN: | 2199-1197 |
| Popis: | BackgroundFenugreek (Trigonella foenum-graecum) seed is a popular kitchen spice and medicinal herb with wide applications in Indian folklore. Earlier studies have shown that the hydro-ethanolic extracts of fenugreek are efficient in the management of a number of hormone related disorders in women, including post and peri-menopausal discomforts, sexual dysfunctions, lactation and even in amenorrhea. However, systematic informations on their safety and influence on hormonal balance are limited.ResultsForty-eight healthy menstruating women aged 20 to 48 were randomized either to FHE (n = 24) or placebo (n = 24) and supplemented with 250 mg × 2/day for 42 days. FHE did not produce any side effects or adverse events. It offered significant (P 1) when monitored by the validated Menopausal Rating Scale (MRS) scale. Further, hormone analysis indicated an enhancement in estradiol (P = 0.040), free testosterone (P = 0.025), and total testosterone (P = 0.012) in FHE group in comparison to placebo. There were no significant changes in progesterone (P = 0.174) and FSH (P = 0.879) upon FHE supplementation. The hematological and biochemical safety parameters were also at par with the safety of the extract.ConclusionThus, the supplementation of FHE may be considered as a natural alternative for sexual issues in women.Trial registrationCTRI/2018/09/015614dated 05/09/2018. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink