Association between polymorphisms in candidate genes and morbid obesity
| Autor: | U Beisiegel, S Ahle, B Kortner, H. W. Kuhlmann, Anna Maria Wolf, U. Nellessen, D Evans |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Candidate gene Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Ion Channels Genetic determinism Body Mass Index Mitochondrial Proteins Polymorphism (computer science) Internal medicine Humans Medicine Uncoupling Protein 2 Receptor Lipoprotein lipase Polymorphism Genetic Nutrition and Dietetics business.industry Body Weight Membrane Transport Proteins Proteins medicine.disease Obesity Thermogenin Obesity Morbid Endocrinology Female Carrier Proteins business Body mass index |
| Zdroj: | International Journal of Obesity. 25:S19-S21 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0801690 |
| Popis: | Polymorphisms in a number of candidate genes have been reported to be associated with obesity. We have determined the incidence of the following polymorphisms in the following candidate genes in a group of 388 morbid obese patients (mean body mass index (BMI) 52+/-8.01) who underwent gastric banding surgery: lipoprotein lipase (LpL) t-93 g and N291S; peroxisome proliferator receptor gamma (PPARgamma), P12A, P115Q and c1431t; peroxisome proliferator receptor alpha (PPARalpha) L162V; beta-adrenergic receptor 2 (beta-AR 2), Q27E; beta-adrenergic receptor 3 (beta-AR 3) W64R; uncoupling protein 1 (ucp-1), a-3826g, ucp-2, 45 bp insertion. Only for the ucp2 polymorphism did we find a statistically significant association with obesity. The beta-AR 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of obesity and may act synergistically. |
| Databáze: | OpenAIRE |
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