Pleurotus tuber-regium mushrooms in the diet of rats ameliorates reproductive and testicular injury caused by carbon tetrachloride
| Autor: | IM Siminialayi, Kenneth Obinna Okolo, Orish Ebere Orisakwe |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
CCl4
0301 basic medicine medicine.medical_specialty Pathology medicine.drug_class lcsh:Medicine lcsh:RX1-681 Antioxidants Male infertility Mushroom 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology lcsh:Homeopathy P. Tuber-regium Internal medicine medicine Sperm analysis Testosterone Sperm motility General Environmental Science business.industry lcsh:R 04 agricultural and veterinary sciences medicine.disease Ascorbic acid Malondialdehyde 040401 food science Sperm Hormones Prolactin 030104 developmental biology Endocrinology chemistry Estrogen General Earth and Planetary Sciences business |
| Zdroj: | Clinical Phytoscience, Vol 3, Iss 1, Pp 1-10 (2017) |
| ISSN: | 2199-1197 |
| DOI: | 10.1186/s40816-017-0051-x |
| Popis: | Background The incidence of male infertility arising from male sexual dysfunction is high especially in the sub saharan Africa. African foods may hold promise to reverse this trend. The aim of this study therefore is to evaluate the improvement of the reproductive and testicular injuries mediated by CCl4 by the use of a wild edible mushroom, P. tuber-regium. Methods Sixty rats were divide into six groups. Group I received 3 mL/kg olive oil by intraperitoneal injections twice weekly. Group II received 3 mL/kg (30% in olive oil) injected twice weekly i.p, Groups III, IV and V received 100 mg, 200 mg and 500 mg wild edible P. tuber-regium (33.3% in feed) daily in addition to 3 mL/kg CCl4 in oil injected twice weekly i.p. Group VI received 500 mg P. tuber-regium (33.3% in feed) daily. After 13 weeks, the animals were sacrificed and testes weighed. Testicular counts and viability were evaluated. Serum levels of FSH, LH, testosterone, estrogen and prolactin were assayed. Malondialdehyde (MDA), ascorbic acid, α-tocopherol, superoxide dismutase (SOD), catalase, total glutathione and peroxidase were determined in testis homogenate. Also, histopathological examinations of the testes were performed. Results Administration of CCl4 to rats significantly (p |
| Databáze: | OpenAIRE |
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