Clinical manifestation of systemic lupus erythematosus in patients with antiribosomal P protein antibodies
| Autor: | Hanna Chwalińska-Sadowska, Ewa Więsik-Szewczyk, Paweł Mielnik, Marzena Olesińska, Jakub Zabek |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Ribosomal Proteins Adolescent Blotting Western Enzyme-Linked Immunosorbent Assay Clinical manifestation Ribosomal P immune system diseases Internal Medicine Humans Lupus Erythematosus Systemic Medicine Clinical significance In patient skin and connective tissue diseases Autoantibodies Lupus erythematosus biology business.industry Autoantibody Middle Aged medicine.disease Blot Immunology biology.protein Female Antibody business |
| Zdroj: | Polish Archives of Internal Medicine. 120:76-81 |
| ISSN: | 1897-9483 |
| DOI: | 10.20452/pamw.891 |
| Popis: | IntroductIon Antibodies against ribosomal P protein (anti‑P) are detected predominantly in pa‑ tients with systemic lupus erythematosus (SLE). However, the data on their frequency and clinical relevance remain inconclusive. objectIves The aim of the study was to assess the frequency as well as clinical and sero logical relevance of anti‑P auto antibodies in Polish patients with SLE and to determine the significance of these antibodies in the diagnosis of SLE. PatIents and methods Anti‑P antibody levels were measured in the sera of 100 SLE patients using an enzyme‑linked immunosorbent assay and Western blotting. All patients underwent a routine clinical and laboratory evaluation. Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. resuLts Anti‑P antibodies were detected in 14 of 100 patients. When compared to anti‑P‑negative patients, this group was characterized by earlier onset of SLE, higher disease activity, more frequent occurrence of fever and facial erythema, decreased serum levels of complement, and elevated levels of alanine and aspartate aminotransferases. In 2 cases, anti‑P antibodies were the only sero logical marker of SLE detected in these patients. concLusIons SLE with the presence of anti‑P antibodies is characterized by an early onset and high disease activity. |
| Databáze: | OpenAIRE |
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