Microenvironment abnormalities and lymphomagenesis: Immunological aspects
| Autor: | Joseph G Taylor, John G. Gribben |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cytotoxicity
Immunologic Cancer Research Lymphoma Antigen-Presenting Cells chemical and pharmacologic phenomena Adaptive Immunity Biology Article Immune tolerance Immunomodulation Immune system Antigen Monitoring Immunologic T-Lymphocyte Subsets Tumor Microenvironment Animals Humans Cytotoxic T cell T-Lymphocytes Helper-Inducer NKG2D Immunity Innate Immunosurveillance Interleukin 10 Cell Transformation Neoplastic Immunology Tumor Escape CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Seminars in Cancer Biology. 34:36-45 |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2015.07.004 |
| Popis: | Innate and adaptive immune cells within the microenvironment identify and eliminate cells displaying signs of malignant potential. Immunosurveillance effector Natural Killer (NK) cells and Cytotoxic T Lymphocyte (CTLs) identify malignant cells through germline receptors such as NKG2D and in the case of CTLs, presentation of antigen through the T cell receptor. Manipulation of immunosurveillance through altered tumor-identifying ligand expression or secretion, resistance to cytotoxicity, or compromised cytotoxic cell activity through immune tolerance mechanisms all contribute to failure of these systems to prevent cancer development. This review examines the diverse mechanisms by which alterations in the immune microenvironment can promote lymphomagenesis. |
| Databáze: | OpenAIRE |
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