Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course
| Autor: | Vimi S Mutalik, Pratik Patel, Shweta Rehani, Raghu Radhakrishnan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Proliferative index Biopsy Article Metastasis Diagnosis Differential medicine Carcinoma Humans Basaloid Squamous Cell Carcinoma Lung medicine.diagnostic_test business.industry Head and neck cancer Mouth Mucosa Clinical course General Medicine Middle Aged medicine.disease medicine.anatomical_structure Carcinoma Squamous Cell Female Mouth Neoplasms business |
| Zdroj: | Case Reports. 2013:bcr2013200441-bcr2013200441 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2013-200441 |
| Popis: | Basaloid squamous cell carcinoma (BSCC) is a rare variant of SCC having a marked predilection for the upper aerodigestive tract. It is regarded as a high-grade tumour with increased propensity for metastasis to distant sites. The histological hallmark of BSCC is its dimorphic pattern of presentation with a characteristic basal cell component associated with squamous component. We report two cases of BSCC on the buccal mucosa and gingiva, respectively, with the former presenting as a primary lesion in a patient without a positive history of tobacco and alcohol use and the latter present as a seemingly metachronous development from carcinoma lung. The proliferative index of the two diverse yet similar entities was assessed by Ki-67 labelling index (LI) and the association of human papillomavirus (HPV) was detected with p16 monoclonal antibody. The intrinsically aggressive behaviour of BSCC and its association with HPV is highlighted. |
| Databáze: | OpenAIRE |
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