Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
| Autor: | Hassan Yankuzo, Norlelawati A.Talib, Seikh Farid Uddin Akter, Rahajoe Imam Santosa, Qamar Uddin Ahmed |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Murraya Curry leaf Kidney Antioxidants Diabetes Mellitus Experimental law.invention Diabetes Complications Rats Sprague-Dawley chemistry.chemical_compound food law Diabetes mellitus Drug Discovery medicine Animals Regeneration Urea Pharmacology chemistry.chemical_classification Creatinine Dose-Response Relationship Drug biology Traditional medicine Plant Extracts business.industry Glutathione peroxidase Malaysia Streptozotocin medicine.disease biology.organism_classification food.food Rats Surgery Plant Leaves medicine.anatomical_structure chemistry Kidney Diseases Phytotherapy business medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 135:88-94 |
| ISSN: | 0378-8741 |
| Popis: | Ethnopharmacological relevance Murraya koenigii (Linn.) Spreng (curry leaf) is widely used as a nephroprotective agent in kidney's infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific evaluation. Aim of the study The present study was designed to investigate the beneficial effect of the leaves of Murraya koenigii (Linn.) on diabetes-induced renal damage in vivo with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. Materials and methods Aqueous (AQ) extract of the leaves of Murraya koenigii (Linn.) was administered to both normal and streptozotocin (STZ) induced diabetic male rats (Sprague–Dawley strain). Animals were divided into six groups (n = 6) and treated with variable dose levels of AQ extract (200 and 400 mg/kg body weight/day) for 30 days. At the end of 30 days, animals were sacrificed, blood was collected, processed and stored at −70 °C for the zestimation of serum urea and creatinine, changes in plasma antioxidant capacity by FRAP assay, and glutathione peroxidase levels, in the normal and STZ-induced diabetic rats. Histological changes of the kidneys of these animals were also evaluated by light microscopy to determine the beneficial effect of the leaves. Results Daily oral administration of variable dose levels of the AQ extract for 30 days, produced significant dose dependant decrease in serum urea and creatinine levels (p |
| Databáze: | OpenAIRE |
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