Women with polycystic ovary syndrome have poorer work ability and higher disability retirement rate at midlife : a Northern Finland Birth Cohort 1966 study
| Autor: | Linda Kujanpää, Riikka K Arffman, Eeva Vaaramo, Henna-Riikka Rossi, Jaana Laitinen, Laure Morin-Papunen, Juha Tapanainen, Leena Ala-Mursula, Terhi T Piltonen |
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| Přispěvatelé: | HUS Gynecology and Obstetrics, Reproductive Disease Modeling, Department of Obstetrics and Gynecology, Clinicum, Helsinki University Hospital Area |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
UNEMPLOYMENT
Retirement Endocrinology Diabetes and Metabolism Work Capacity Evaluation General Medicine Middle Aged 3142 Public health care science environmental and occupational health WEIGHT-GAIN PREVALENCE Cohort Studies PAID EMPLOYMENT Endocrinology 3123 Gynaecology and paediatrics Humans Birth Cohort Female Prospective Studies HEALTH FERTILE AGE FOLLOW-UP PREDICTORS Finland POPULATION INDEX Polycystic Ovary Syndrome |
| Popis: | Objective Polycystic ovary syndrome (PCOS) presents with multiple comorbidities potentially affecting function. This was the first general population-based study to evaluate work ability, participation in working life, and disability retirement in middle-aged women with and without PCOS. Design This is a cohort study. Methods Women with PCOS (n = 280) and women without PCOS symptoms or diagnosis (n = 1573) were identified in the Northern Finland Birth Cohort in 1966 and were evaluated for self-rated work ability and potential confounders at age 46. Next, incidence rate ratios (IRRs) for disability and unemployment days were extracted from national registers during a prospective 2-year follow-up. Lastly, we assessed hazard ratios (HRs) for disability retirement between 16 and 52 years of age from national registers. Results The women with PCOS reported poorer ability to work at age 46, especially due to poorer health. During the 2-year follow-up period, the affected women gained on average an additional month of disability and unemployment days, corresponding to an approximately 25% higher risk for both disability (IRR (95% CI): 1.25 (1.22–1.27)) and unemployment days (IRR (95% CI): 1.26 (1.23–1.28)) in models adjusted for health and socioeconomic factors. Lastly, we found a two-fold higher cumulative risk for disability retirement by age 52 compared to non-PCOS women (HR (95% CI): 1.98 (1.40–2.80)), which remained after adjusting for confounding factors (aHR (95% CI): 1.55 (1.01–2.38)). Conclusions PCOS is associated with lower participation in working life already in midlife. Acknowledging PCOS-related multimorbidity, concerted efforts are needed to support sustainable careers for women with PCOS. |
| Databáze: | OpenAIRE |
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