Cholinergic signalling mechanisms and early implant healing phases in healthy versus generalized aggressive periodontitis patients: A prospective, case–control study
| Autor: | Burcu Kanmaz, Christopher J. Nile, Nurcan Buduneli, Gareth Calvert, David F. Lappin, Erhan Çömlekoğlu, Pınar Meriç, Önder Gürlek |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
implants
Cholinergic Agents Osseointegration esterases 03 medical and health sciences 0302 clinical medicine medicine Humans Aggressive periodontitis Prospective Studies 030212 general & internal medicine periodontitis Cholinesterase Dental Implants Periodontitis biology business.industry Case-control study Gingival Crevicular Fluid 030206 dentistry medicine.disease acetylcholine SLURP-1 Aggressive Periodontitis Case-Control Studies Immunology biology.protein Periodontics Cholinergic Implant business Acetylcholine medicine.drug |
| Zdroj: | Journal of Clinical Periodontology. 46:1155-1163 |
| ISSN: | 1600-051X 0303-6979 |
| DOI: | 10.1111/jcpe.13185 |
| Popis: | PubMed: 31444906 Aims: Periodontal diseases negatively affect implant osseointegration. Perturbations in non-neuronal cholinergic signalling mechanisms are associated with periodontitis; however, their role in generalized aggressive periodontitis (GAgP) is unknown. The aim of this prospective case–control study was to determine the relationship between non-neuronal cholinergic signalling mechanisms, secreted Ly-6/uPAR-related protein-1 (SLURP-1), interleukin-17 (IL-17) family cytokines and healing of dental implants in health and GAgP. Material and Methods: Thirteen GAgP patients and seven periodontally healthy individuals (PH) were recruited. Peri-implant crevicular fluid (PICF) was obtained at baseline and 1 month post-placement. Acetylcholine (ACh) levels and cholinesterase activity were determined biochemically. SLURP-1, IL-17A and IL-17E levels were determined by ELISA. Marginal bone loss (MBL) at 1 and 6 months post-placement was determined radiographically. Results: The concentration of ACh, cholinesterase activity and IL-17A levels was elevated in PICF of patients with GAgP compared to PH individuals at baseline and 1 month post-placement. The concentration of ACh and cholinesterase activity levels in PICF correlated with levels of IL-17A and MBL around implants 1 month post-placement in patients with GAgP. Conclusions: Non-neuronal cholinergic mechanisms may play a role in the aetiopathogenesis of GAgP and may directly or indirectly, through modulation of IL-17A, influence early implant osseointegration and potential long-term implant survival. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| Databáze: | OpenAIRE |
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