Establishment and characterization of a novel VEGF-producing HHV-8-unrelated PEL-like lymphoma cell line, OGU1
| Autor: | Hiroshi Sakura, Motohiko Aiba, Kiyotaka Kawauchi, Toshie Ogasawara, Masabumi Shibuya, Tsutomu Sanaka, Mariko Fujibayashi |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 0301 basic medicine Pathology medicine.medical_specialty viruses medicine.medical_treatment Gene Expression Biology Capillary Permeability 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine BCL9 immune system diseases Cell Line Tumor Lymphoma Primary Effusion hemic and lymphatic diseases medicine Humans B-cell lymphoma Aged B-Lymphocytes Vascular Endothelial Growth Factor Receptor-1 Cell growth Growth factor virus diseases Herpesviridae Infections Hematology General Medicine biochemical phenomena metabolism and nutrition medicine.disease Founder Effect BCL10 Lymphoma Vascular endothelial growth factor 030104 developmental biology chemistry 030220 oncology & carcinogenesis Herpesvirus 8 Human Primary effusion lymphoma |
| Zdroj: | European Journal of Haematology. 96:144-151 |
| ISSN: | 0902-4441 |
| Popis: | Primary effusion lymphoma (PEL) is a rare B-cell lymphoma subtype that is characterized by lymphomatous effusion without the presence of masses, and it typically occurs in human immunodeficiency virus (HIV)-infected individuals. Lymphoma cells are universally positive for human herpesvirus 8 (HHV-8). Recently, a cavity-based effusion lymphoma that is similar to PEL without HHV-8 infection, called HHV-8-unrelated PEL-like lymphoma, has been reported in non-HIV-infected individuals. However, the pathophysiology of this lymphoma is largely undefined. We established a novel B-cell line OGU1 derived from a patient with HHV-8-unrelated PEL-like lymphoma. Notably, OGU1 cells produced vascular endothelial growth factor (VEGF) and expressed VEGF receptor 1, whose inhibitors retarded cell growth. Because VEGF acts as a vascular permeability and growth factor, it could play a role, at least in part, in the pathogenesis of this unique lymphoma. Thus, the OGU1 cell line is useful for the investigation of HHV-8-unrelated PEL-like lymphoma. |
| Databáze: | OpenAIRE |
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