Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles
| Autor: | Shuiming Xiao, Jie Wang, Feng Sui, Yanjun Chen, Qiaoxin Yue, Qinghe Zhao, Zhenzhen Li, Hai Ma, Gejing De, Huatao Yu |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Paclitaxel Cell Survival Polymers medicine.medical_treatment Cell Biomedical Engineering Medicine (miscellaneous) Bioengineering Breast Neoplasms 02 engineering and technology Development Micelle Metastasis 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Drug Delivery Systems Coumarins Cell Line Tumor medicine Animals Humans General Materials Science Micelles Chemotherapy Tumor microenvironment Drug Carriers Mice Inbred BALB C Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology medicine.disease Antineoplastic Agents Phytogenic medicine.anatomical_structure Biochemistry chemistry 030220 oncology & carcinogenesis Drug delivery Cancer research Female 0210 nano-technology Drug carrier |
| Zdroj: | Nanomedicine (London, England). 12(2) |
| ISSN: | 1748-6963 |
| Popis: | Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(β-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis. Materials & methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice. Results: PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis. Conclusion: The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis. |
| Databáze: | OpenAIRE |
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