Superparamagnetic Fe3O4 Nanoparticles: Synthesis by Thermal Decomposition of Iron(III) Glucuronate and Application in Magnetic Resonance Imaging
| Autor: | Vít Herynek, Lucie Kosinová, Aleksandra Paruzel, Daniel Horák, Rafał Konefał, Mariia Rabyk, Marija Lovrić, Lejla Ferhatović Hamzić, Srećko Gajović, Miroslav Šlouf, Vitalii Patsula |
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| Rok vydání: | 2016 |
| Předmět: |
iron oxide
magnetic resonance imaging nanoparticles superparamagnetic thermal decomposition Materials science Glucuronate Analytical chemistry Contrast Media Nanoparticle 02 engineering and technology 010402 general chemistry Ferric Compounds 01 natural sciences Glucuronic Acid Dynamic light scattering Animals General Materials Science Fourier transform infrared spectroscopy Magnetite Nanoparticles Thermal decomposition 021001 nanoscience & nanotechnology Magnetic Resonance Imaging Rats 0104 chemical sciences Electron diffraction Rats Inbred Lew Attenuated total reflection Rats Transgenic 0210 nano-technology Superparamagnetism |
| Zdroj: | ACS Applied Materials & Interfaces. 8:7238-7247 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Monodisperse superparamagnetic Fe3O4 nanoparticles coated with oleic acid were prepared by thermal decomposition of Fe(III) glucuronate. The shape, size, and particle size distribution were controlled by varying the reaction parameters, such as the reaction temperature, concentration of the stabilizer, and type of high-boiling-point solvents. Magnetite particles were characterized by transmission electron microscopy (TEM), as well as electron diffraction (SAED), X-ray diffraction (XRD), dynamic light scattering (DLS), and magnetometer measurements. The particle coating was analyzed by atomic absorption spectroscopy (AAS) and attenuated total reflection (ATR) Fourier transform infrared spectroscopy (FTIR) spectroscopy. To make the Fe3O4 nanoparticles dispersible in water, the particle surface was modified with α-carboxyl-ω-bis(ethane-2, 1-diyl)phosphonic acid-terminated poly(3-O-methacryloyl-α-D- glucopyranose) (PMG–P). For future practical biomedical applications, nontoxicity plays a key role, and the PMG–P&Fe3O4 nanoparticles were tested on rat mesenchymal stem cells to determine the particle toxicity and their ability to label the cells. MR relaxometry confirmed that the PMG–P&Fe3O4 nanoparticles had high relaxivity but rather low cellular uptake. Nevertheless, the labeled cells still provided visible contrast enhancement in the magnetic resonance image. In addition, the cell viability was not compromised by the nanoparticles. Therefore, the PMG–P&Fe3O4 nanoparticles have the potential to be used in biomedical applications, especially as contrast agents for magnetic resonance imaging. |
| Databáze: | OpenAIRE |
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