STOP proteins contribute to the maturation of the olfactory system
| Autor: | Annie Schweitzer, Marion Richard, François Jourdan, Véronique Pellier-Monnin, Joëlle Sacquet, Annie Andrieux, Marion Jany |
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| Přispěvatelé: | Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), IFR des neurosciences de Lyon (IFNL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Centre Hospitalier le Vinatier [Bron]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Andrieux, Annie |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Olfactory system
MESH: Protein Isoforms Microtubules MESH: Mice Knockout MESH: Vomeronasal Organ Tissue Culture Techniques Mice 0302 clinical medicine Olfactory bulb MESH: Pregnancy Olfactory nerve Pregnancy Protein Isoforms MESH: Animals MESH: Nerve Tissue Proteins Cytoskeleton Mice Knockout Mice Inbred BALB C 0303 health sciences Olfactory Pathways Cell biology medicine.anatomical_structure Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Vomeronasal Organ Microtubule-Associated Proteins MESH: Rats MESH: Mice Inbred BALB C Nerve Tissue Proteins Sensory system Biology Olfactory Receptor Neurons 03 medical and health sciences Cellular and Molecular Neuroscience Microtubule Neuropil medicine Animals Axon outgrowth [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Tissue Culture Techniques Rats Wistar Molecular Biology MESH: Mice 030304 developmental biology Cell Biology MESH: Rats Wistar MESH: Olfactory Receptor Neurons Rats MESH: Microtubule-Associated Proteins nervous system Olfactory ensheathing glia Neuroscience MESH: Female 030217 neurology & neurosurgery MESH: Olfactory Pathways |
| Zdroj: | Molecular and Cellular Neuroscience Molecular and Cellular Neuroscience, Elsevier, 2009, 41 (2), pp.120-34. ⟨10.1016/j.mcn.2009.02.004⟩ Molecular and Cellular Neuroscience, 2009, 41 (2), pp.120-34. ⟨10.1016/j.mcn.2009.02.004⟩ |
| ISSN: | 1044-7431 1095-9327 |
| DOI: | 10.1016/j.mcn.2009.02.004⟩ |
| Popis: | International audience; Regulation of microtubule dynamics is crucial for axon growth and guidance as well as for the establishment of synaptic connections. STOPs (Stable Tubule Only Polypeptides) are microtubule-associated proteins that regulate microtubule stabilization but are also able to interact with actin or Golgi membranes. Here, we have investigated the involvement of STOPs during the development of the olfactory system. We first describe the spatio-temporal expression patterns of N- and E-STOP, the two neuronal-specific isoforms of STOP. E- and N-STOP are expressed in the axonal compartment of olfactory sensory neurons, but are differentially regulated during development. Interestingly, each neuronal isoform displays a specific gradient distribution within the olfactory nerve layer. Then, we have examined the development of the olfactory system in the absence of STOPs. Olfactory axons display a normal outgrowth and targeting in STOP-null mice, but maturation of the synapses in the glomerular neuropil is altered. |
| Databáze: | OpenAIRE |
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