Differential effects of acute and chronic social defeat stress on hypothalamic-pituitary-adrenal axis function and hippocampal serotonin release in mice

Autor: Sandy Hogg, R. E. Blackburn-Munro, Charles A. Marsden, Adam J Keeney, Michael S. Harbuz, David S. Jessop
Rok vydání: 2006
Předmět:
Dominance-Subordination
Male
endocrine system
medicine.medical_specialty
Vasopressin
Hypothalamo-Hypophyseal System
Serotonin
Corticotropin-Releasing Hormone
Endocrinology
Diabetes and Metabolism
Microdialysis
Pituitary-Adrenal System
Adrenocorticotropic hormone
Social Environment
Hippocampus
Social defeat
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Mice
Endocrinology
Adrenocorticotropic Hormone
Corticosterone
Internal medicine
medicine
Animals
Chronic stress
RNA
Messenger
Neurotransmitter
Endocrine and Autonomic Systems
Immobility Response
Tonic
Arginine Vasopressin
medicine.anatomical_structure
chemistry
Hypothalamus
Psychology
hormones
hormone substitutes
and hormone antagonists
Hypothalamic–pituitary–adrenal axis
Stress
Psychological
Paraventricular Hypothalamic Nucleus
Zdroj: Journal of neuroendocrinology. 18(5)
ISSN: 0953-8194
Popis: Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) stress axis and disturbances in serotonin (5-HT) neurotransmission have been implicated in the pathogenesis of depressive disorder. Repeated social defeat of male NMRI mice has been shown to induce increases in core body temperature and corticosterone, indicative of a state of chronic stress in subordinate animals. The present study further characterised the HPA axis response to social defeat stress, and also examined hippocampal extracellular 5-HT release during the stress. Exposure to an acute social defeat elicits increases in plasma adrenocorticotrophic hormone and corticosterone levels, peaking at 15 and 30 min, respectively, and enhances corticotrophin-releasing factor (CRF) mRNA, but not arginine vasopressin (AVP) mRNA within the medial parvocellular division of the hypothalamic paraventricular nucleus. A concomitant increase in hippocampal corticosterone and 5-HT levels is observed. By contrast, although chronic social defeat is associated with greatly elevated corticosterone levels, the predominant drive appears to be via parvocellular AVP rather than CRF. Furthermore, subordinate animals allowed to recover for 9 days after chronic social defeat display an increase in immobility in the forced swimming model of depression, indicating that animals previously exposed to the homotypic defeat stress are sensitised to the behavioural effects of a novel stressor. These results demonstrate that social defeat induces prolonged activation of the HPA axis and alterations in 5-HT neurotransmission that could be of relevance to some of the pathological abnormalities observed in clinical depression.
Databáze: OpenAIRE
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