Effects of Whole Grain Intake, Compared to Refined Grain, on Glycemia and Insulinemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
| Autor: | Katie Koecher, Lisa M. Sanders, Kevin C. Maki, Meredith L. Wilcox, Yong Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry Insulin medicine.medical_treatment Medicine (miscellaneous) Insulin sensitivity medicine.disease Whole grains law.invention Endocrinology Insulin resistance Randomized controlled trial law Meta-analysis Internal medicine medicine Energy and Macronutrient Metabolism Fasting blood glucose measurement Hemoglobin business Food Science |
| Zdroj: | Curr Dev Nutr |
| Popis: | OBJECTIVES: Epidemiological study results suggest that whole grain (WG) consumption is associated with a reduced risk of type 2 diabetes; however, the potential mechanism behind this observation is unclear. WG intake may lower postprandial glycemia and insulinemia and improve insulin sensitivity, thereby contributing to a reduced risk of type 2 diabetes. The objective of this systematic review and meta-analysis was to evaluate the impact of WG on postprandial glycemia and insulinemia and markers of glycemic control and insulin sensitivity/resistance. METHODS: A systematic review and meta-analysis was conducted on randomized controlled trials (RCTs) evaluating the effect of WG intake, compared to refined grain (RG) intake, on postprandial glycemia and insulinemia area under the curve and markers of glycemic control and insulin sensitivity/resistance in adults. A search of PubMed and Scopus yielded 80 relevant RCTs. Pooled estimates were expressed as standardized mean differences (SMD) between the WG intervention and RG control group. RESULTS: WG intake resulted in a significant reduction of postprandial glycemia (SMD: −0.46, 95% CI: −0.59, −0.33, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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