Mitochondrial dysfunction and the inflammatory response
| Autor: | Carlos Vaamonde-García, María J. López-Armada, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Inflammation
Inflammatory response Acute diseases Inflammasome Cell Biology Mitochondrion Biology medicine.disease_cause Mitochondria Mitochondrial autophagy Cell biology Oxidative Stress Immunology medicine Humans Molecular Medicine medicine.symptom Molecular Biology Oxidative stress Function (biology) medicine.drug |
| Zdroj: | Mitochondrion. 13:106-118 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2013.01.003 |
| Popis: | Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter mitochondrial function. Both of these processes increase mitochondrial oxidative stress, promoting a vicious inflammatory cycle. Additionally, damage-associated molecular patterns derived from mitochondria could contribute to inflammasome formation and caspase-1 activation, while alterations in mitochondrial autophagy may cause inflammation. Strategies aimed at controlling excessive oxidative stress within mitochondria may represent both preventive and therapeutic interventions in inflammation. |
| Databáze: | OpenAIRE |
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