Short Communication: Integrase Strand Transfer Inhibitors Drug Resistance Mutations in Puerto Rico HIV-Positive Individuals
| Autor: | Andrea Arias, Grissell Tirado, Elliott R Rodríguez-López, Raphael Sánchez, Pablo H.H. Lopez, Vanessa Rivera-Amill |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pyridones
Health Toxicology and Mutagenesis lcsh:Medicine Integrase inhibitor HIV Infections Drug resistance 03 medical and health sciences chemistry.chemical_compound Drug Resistance Viral integrase resistance mutations medicine Humans HIV Integrase Inhibitors 030304 developmental biology 0303 health sciences Bictegravir biology bictegravir 030306 microbiology Elvitegravir Communication Puerto Rico lcsh:R Public Health Environmental and Occupational Health Raltegravir Virology Reverse transcriptase Integrase dolutegravir chemistry Mutation Dolutegravir biology.protein HIV-1 elvitegravir raltegravir medicine.drug |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 2719, p 2719 (2021) |
| ISSN: | 1660-4601 1661-7827 |
| Popis: | The HIV-1 integrase viral protein is responsible for incorporating the viral DNA into the genomic DNA. The inhibition of viral integration into host cell DNA is part of recent therapeutic procedures. Combination therapy with protease and reverse transcriptase inhibitors has demonstrated good synergistic results in reducing viral replication. The purpose of this study is to assess the occurrence of integrase drug resistance mutations from the period comprising 2013 through 2018 in Puerto Rico (PR). We analyzed 131 nucleotide sequences available in our HIV genotyping database, and we performed drug resistance mutation analyses using the Stanford HIV Drug Resistance Database. Twenty-one sequences (16.03%) harbored major or resistance-associated mutations. We identified the Q148HKR, G140S, Y143R, N155H, S147G, and E138EA major drug resistance mutations and the D232DN, T97TA, E157Q, G163GART accessory mutations. We detected high-level drug resistance to Elvitegravir and Raltegravir (76.19% and 85.71%). Moreover, we identified sequences harboring drug resistance mutations that could provide resistance to Dolutegravir. The transmission of strains with integrase antiretroviral resistance has been previously documented in treatment naïve patients. Given the increase of patients treated with integrase inhibitors, surveillance of drug resistance mutations is an essential aspect of PR’s clinical management of HIV infection. |
| Databáze: | OpenAIRE |
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